The Diffusion of Regulatory Oversight [PDF]
, 2013 The idea of cost-benefit analysis has been spreading internationally for centuries — at least since an American named Benjamin Franklin wrote a letter in 1772 to his British friend, Joseph Priestley, recommending that Priestley weigh the pros and cons of
Wiener, Jonathan B.
core +2 more sources
Crosstalk between the ribosome quality control‐associated E3 ubiquitin ligases LTN1 and RNF10
FEBS Letters, EarlyView.Loss of the E3 ligase LTN1, the ubiquitin‐like modifier UFM1, or the deubiquitinating enzyme UFSP2 disrupts endoplasmic reticulum–ribosome quality control (ER‐RQC), a pathway that removes stalled ribosomes and faulty proteins. This disruption may trigger a compensatory response to ER‐RQC defects, including increased expression of the E3 ligase RNF10 ...
Yuxi Huang +8 more
wiley +1 more source
Legislative Alert: The Regulations from the Executive in Need of Scrutiny (the REINS Act), the Regulatory Accountability Act and the Regulatory Flexibility Improvements Act (H.R.10) (H.R.3010) (H.R. 527) [PDF]
, 2011 [Excerpt] When the Congress returns from the Thanksgiving break the House is expected to vote on three regulatory reform\u27* bills - H.R. 10, the Regulations from the Executive in Need of Scrutiny (the REINS Act). H.R.
Samuel, William
core +1 more source
Metabolic support of tumor-infiltrating regulatory T cells by lactic acid
Nature, 2020 Regulatory T (Treg) cells, although vital for immune homeostasis, also represent a major barrier to anti-cancer immunity, as the tumour microenvironment (TME) promotes the recruitment, differentiation and activity of these cells1,2.
M. Watson +16 more
semanticscholar +1 more source
Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation
FEBS Letters, EarlyView.Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe +3 more
wiley +1 more source
Fintech, regulatory arbitrage, and the rise of shadow banks
Journal of Financial Economics, 2018 Shadow bank market share in residential mortgage origination nearly doubled from 2007 to 2015, with particularly dramatic growth among online “fintech” lenders.
Greg Buchak +3 more
semanticscholar +1 more source
Function‐driven design of a surrogate interleukin‐2 receptor ligand
FEBS Letters, EarlyView.Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang +9 more
wiley +1 more source
Elongate hemlock scale, an exotic scale insect pest of Christmas trees and other conifers
EDIS, 2019 Elongate hemlock scale, Fiorinia externa Ferris (Hemiptera: Diaspididae), is an armored scale insect native to Japan and eastern Asia. This insect was first documented in the United States in 1908 in Queens, NY, and has since spread throughout most of ...
Adam G. Dale +2 more
doaj +1 more source
TRRUST v2: an expanded reference database of human and mouse transcriptional regulatory interactions
Nucleic Acids Res., 2017 Transcription factors (TFs) are major trans-acting factors in transcriptional regulation. Therefore, elucidating TF–target interactions is a key step toward understanding the regulatory circuitry underlying complex traits such as human diseases.
Heonjong Han +19 more
semanticscholar +1 more source
Multiple ETS family transcription factors bind mutant p53 via distinct interaction regions
FEBS Letters, EarlyView.Mutant p53 gain‐of‐function is thought to be mediated by interaction with other transcription factors. We identify multiple ETS transcription factors that can bind mutant p53 and found that this interaction can be promoted by a PXXPP motif. ETS proteins that strongly bound mutant p53 were upregulated in ovarian cancer compared to ETS proteins that ...
Stephanie A. Metcalf +6 more
wiley +1 more source