Results 81 to 90 of about 269,212 (236)

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Acetylation as a dynamic regulatory interface between plant stress memory, cross-tolerance, and crop resilience design

Frontiers in Plant Science
Plants are increasingly exposed to recurrent, combined, and fluctuating environmental stresses, making it essential to understand how transient stress signals are converted into durable adaptive states.
Rongjin Ma, Xianjue Ruan, Xinchen Niu, Qingyuan Li, Jing Wen, Yu Pan, Chunyu Shang   +6 more
doaj   +1 more source

Discerning protein pools by selective staining with self‐labeling tags

FEBS Letters, EarlyView.
Cell surface proteins have an intra‐ and extracellular pool. Combining genetic fusion to self‐labeling tags that can be addressed with small molecule fluorophores allows separating these pools. We highlight recent developments and techniques for state‐of‐the‐art interrogation of cell surface proteins in the complex tissue setting.
Kati Fischermanns, Johannes Broichhagen
wiley   +1 more source

Nutrient/TOR signaling controls adipose mitochondrial transcription factor A (TFAM) to regulate organismal growth in Drosophila

FEBS Letters, EarlyView.
Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas, Shahoon Khan, Abhishek Sharma, Byoungchun Lee, Savraj S. Grewal   +4 more
wiley   +1 more source

Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics

FEBS Letters, EarlyView.
Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt, Ana‐Maria Sandru, Georg Vucak, Sebastian Didusch, Biljana Riemelmoser, Karin Ehrenreiter, Markus Hartl, Lukas A. Huber, Manuela Baccarini   +8 more
wiley   +1 more source

CORRELATION BETWEEN THE LEVEL OF STRESS RESISTANCE AND PROGESTERONE CONCENTRATION IN A HEALTHY WOMEN'S BLOOD IN THE LUTEAL PHASE OF THE MENSTRUAL CYCLE

Кубанский научный медицинский вестник, 2016
The purpose of this work is to identify the relationship between concentration of progesterone in blood and stress healthy women. Material and methods.
V. V. Yeremenko, E. G. Potyagailo, V. G. Abushkevich, V. M. Bondina, A. P. Storozhuk   +4 more
doaj  

Epigenetic reprogramming of lineage switching in cancer

FEBS Letters, EarlyView.
Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı, Burcu Akman, Ezgi Bağırsakçı, Nese Atabey, Serap Erkek‐Ozhan   +4 more
wiley   +1 more source

Integrating Al-‘Urf into Smart Contracts: Addressing Regulatory Challenges in Blockchain-Based Waqf Governance

Jurnal Hukum Islam
The integration of blockchain technology into waqf system opens opportunities for transforming digital waqf governance by increasing transparency, efficiency, and accountability.
Sofian Al-hakim, Adang Sonjaya , Opik Rozikin , Asas Worasutr , Jaenal Aripin   +4 more
doaj   +1 more source

The microbiome in human skin aging

FEBS Letters, EarlyView.
Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana, Cornelia Wiegand, Omid Omrani, Mario Fabri   +3 more
wiley   +1 more source

Maternal and fetal heart rate variability in patients with gestational diabetes mellitus

Фундаментальная и клиническая медицина
Aim. To study regulatory processes in the maternal-placental-fetal system in gestational diabetes mellitus to identify differences in their nature depending on the development of fetal macrosomia.Materials and Methods.
O. N. Novikova, O. V. Glazovskaya
doaj   +1 more source