Nonlinearity arising from noncooperative transcription factor binding enhances negative feedback and promotes genetic oscillations [PDF]
We study the effects of multiple binding sites in the promoter of a genetic oscillator. We evaluate the regulatory function of a promoter with multiple binding sites in the absence of cooperative binding, and consider different hypotheses for how the ...
Lengyel, Iván M. +3 more
core +3 more sources
Reciprocal control of viral infection and phosphoinositide dynamics
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley +1 more source
By dawn or dusk—how circadian timing rewrites bacterial infection outcomes
The circadian clock shapes immune function, yet its influence on infection outcomes is only beginning to be understood. This review highlights how circadian timing alters host responses to the bacterial pathogens Salmonella enterica, Listeria monocytogenes, and Streptococcus pneumoniae revealing that the effectiveness of immune defense depends not only
Devons Mo +2 more
wiley +1 more source
Prevention Focus Relates to Performance on a Loss-Framed Inhibitory Control Task
Information framing can be critical to the impact of information and can affect individuals differently. One contributing factor is a person’s regulatory focus, which describes their focus on achieving gains vs. avoiding losses.
Benjamin T. Files +6 more
doaj +1 more source
The effects of regulatory focus and mixed valence imagery and analytical attributes on product decisions [PDF]
Purpose The purpose of this paper is to investigate the effects of regulatory focus (promotion vs prevention) and mixed valence attributes (positive imagery and negative analytical vs negative imagery and positive analytical) on consumers’ evaluation ...
Roy, Rajat
core +1 more source
The role and implications of mammalian cellular circadian entrainment
At their most fundamental level, mammalian circadian rhythms occur inside every individual cell. To tell the correct time, cells must align (or ‘entrain’) their circadian rhythm to the external environment. In this review, we highlight how cells entrain to the major circadian cues of light, feeding and temperature, and the implications this has for our
Priya Crosby
wiley +1 more source
The relationship between metamotivational knowledge and performance
Self-regulation research highlights the performance trade-offs of different motivational states. For instance, within the context of regulatory focus theory, promotion motivation enhances performance on eager tasks and prevention motivation enhances ...
Jessica Ross +5 more
doaj +1 more source
Molecular bases of circadian magnesium rhythms across eukaryotes
Circadian rhythms in intracellular [Mg2+] exist across eukaryotic kingdoms. Central roles for Mg2+ in metabolism suggest that Mg2+ rhythms could regulate daily cellular energy and metabolism. In this Perspective paper, we propose that ancestral prokaryotic transport proteins could be responsible for mediating Mg2+ rhythms and posit a feedback model ...
Helen K. Feord, Gerben van Ooijen
wiley +1 more source
Sales Control Systems and Behavioral Responses
Built on regulatory focus theory, this article develops a research model proposing the relationship between management controls (outcome, activity and capability), sales employees’ prevention and promotion focus and their behavioral responses (feedback ...
Jaewon Yoo
doaj +1 more source
Ensuring intervention success: Assessing fit as an overlooked step of the implementation process
Ensuring fit between a service and the implementing context is a critical but often overlooked precursor of implementation success. This commentary proposes five key considerations that should be evaluated when exploring fit: alignment with needs and ...
Carrie M. Blanchard , Melanie Livet
doaj +1 more source

