Results 81 to 90 of about 1,617,487 (313)

Commercial Law – Break fees – issues for corporate lawyers [PDF]

, 1999
The authors discuss the use of break or termination fees, such as those utilised in US takeover arrangements, and consider their applicability for UK corporate law, regulatory issues and market practice.
Shilling, Helen, Walter, Jerry
core  

Implementing Loss Distribution Approach for Operational Risk

, 2009
To quantify the operational risk capital charge under the current regulatory framework for banking supervision, referred to as Basel II, many banks adopt the Loss Distribution Approach.
Artzner, Aue, Basel Committee on Banking Supervision, Bedard, Berger, Böcker, Böcker, Böcker, Böcker, Bühlmann, Bühlmann, Chavez-Demoulin, Chernobai, Chernobai, Cont, Cruz, Dalla Valle, Degen, Efron, Embrechts, Embrechts, Embrechts, Embrechts, Embrechts, Ergashev, Frachot, Gerhold, Giacometti, Gilks, Gustafsson, Hess, Joe, Johnson, King, Klugman, Lambrigger, Lehmann, Lindskog, Luo, Luo, Marshall, McNeil, Mignola, Mignola, Nelson, Nešlehová, Panjer, Peters, Peters, Peters, Peters, Powojowski, Press, Robert, Sandström, Schaller, Shevchenko, Shevchenko, Shevchenko, Sundt, Wüthrich   +60 more
core   +2 more sources

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Regulating the AI-enabled ecosystem for human therapeutics

Communications Medicine
Recent advances in artificial intelligence (AI) tools and techniques can revolutionize the discovery, development, manufacturing, and delivery of new medicines by reducing the time and cost involved.
Rominder Singh, Mark Paxton, Jared Auclair   +2 more
doaj   +1 more source

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Evaluation of Air Transportation Under Controlled Room Temperature for Pharmaceuticals

Promet (Zagreb), 2011
Pharmaceutical industry like aviation is one of the most regulated industries today. Shipping pharmaceutical products under defined time and temperature conditions is a challenge deriving from regulatory and product quality aspects.
Gordan Badurina, Zvonimir Majić, Stanislav Pavlin   +2 more
doaj   +1 more source

The Regulatory Orthodoxy in Practice

, 2007
This paper examines whether the OECD regulatory model corresponds with regulatory practice in Norway. It describes and analyzes whether civil servants in central agencies working with regulatory tasks differ from other civil servants when it comes to the importance of professional considerations and signals from their parent ministry and political ...
Christensen, Tom, Lægreid, Per
openaire   +1 more source

Linking neurogenesis, oligodendrogenesis, and myelination defects to neurodevelopmental disruption in primary mitochondrial disorders

FEBS Letters, EarlyView.
Mitochondrial remodeling shapes neural and glial lineage progression by matching metabolic supply with demand. Elevated OXPHOS supports differentiation and myelin formation, while myelin compaction lowers mitochondrial dependence, revealing mitochondria as key drivers of developmental energy adaptation.
Sahitya Ranjan Biswas, Porter L. Tomsick, Alicia M. Pickrell, Paul D. Morton   +3 more
wiley   +1 more source

Comprehensive Patterns Concerning BA/BE Studies and Biowaivers in the Regulatory Approval of Generic Pharmaceuticals in the United States, the EU, and India

Advances in Pharmacological and Pharmaceutical Sciences
This analysis studies the pharmaceutical approval policy regarding generics in the United States and European and Indian markets. Therapeutically equivalent generics are therefore considered safe, effective, and of comparable quality to their name-brand ...
Rakan Alsaqer, Ankitha M. S., Samathoti Prasanthi, Prakash Goudanavar, Mahesh Namballa, N. Raghavendra Naveen, Krishna Swaroop, Girish Meravanige, Nagaraja Sreeharsha, Afzal Haq Asif   +9 more
doaj   +1 more source

The US Food and Drug Administration's authorisation of Purdue's controlled-release methylphenidate for adult ADHD: comments on the regulatory practice. [PDF]

J R Soc Med, 2021
Boesen K, Juhl Jørgensen K, Gøtzsche PC.   +2 more
europepmc   +1 more source