Results 141 to 150 of about 7,752,988 (327)

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

Linking neurogenesis, oligodendrogenesis, and myelination defects to neurodevelopmental disruption in primary mitochondrial disorders

FEBS Letters, EarlyView.
Mitochondrial remodeling shapes neural and glial lineage progression by matching metabolic supply with demand. Elevated OXPHOS supports differentiation and myelin formation, while myelin compaction lowers mitochondrial dependence, revealing mitochondria as key drivers of developmental energy adaptation.
Sahitya Ranjan Biswas, Porter L. Tomsick, Alicia M. Pickrell, Paul D. Morton   +3 more
wiley   +1 more source

Current situation and issues regarding termination of risk management plans in Japan

Frontiers in Medicine
IntroductionIn Japan, drugs approved after the 2013 implementation of the risk management plan (RMP) have the opportunity to be evaluated for RMP termination. However, the guidelines for risk management following the termination of an RMP remain unclear.
Natsuko Kameyama, Aoi Hosaka, Hideki Maeda, Hideki Maeda   +3 more
doaj   +1 more source

An isoform of 14‐3‐3 protein regulates transbilayer lipid movement at the plasma membrane

FEBS Letters, EarlyView.
Loss of 14‐3‐3ζ in CHO cells confers resistance to exogenous phosphatidylserine (PS) and impairs endocytosis‐independent inward flip‐flop of fluorescent PS at the plasma membrane. RNAi‐mediated knockdown reproduces this defect, while no additive effect is seen in ATP11C‐deficient cells.
Akiko Yamaji‐Hasegawa, Akira Hattori, Masafumi Tsujimoto, Toshihide Kobayashi   +3 more
wiley   +1 more source

Systematic review and meta-analysis on fully automated digital cognitive behavioral therapy for insomnia

npj Digital Medicine
Insomnia impairs daily functioning and increases health risks. Cognitive behavioral therapy for insomnia (CBT-I) is effective but limited by cost and therapist availability.
Ji Woo Hwang, Ga Eun Lee, Jae Hyun Woo, Sung Min Kim, Ji Yean Kwon   +4 more
doaj   +1 more source

Florida Geological Survey [PDF]

The Florida Geological Survey (FGS) homepage provides data, research materials and interpretations on aquifer systems, geologic frameworks, landforms, energy and non-energy mineral resources, and geologic hazards which which can be used to address issues

core   +2 more sources

The ubiquitin ligase RNF115 is required for the clearance of damaged lysosomes

FEBS Letters, EarlyView.
Upon lysosomal rupture, an E3 ubiquitin ligase RNF115 translocates from the cytosol to the damaged lysosomal membrane. Moreover, RNF115 depletion impairs the clearance of damaged lysosomes, identifying it as a key regulator of lysosomal quality control.
Sae Nakanaga, Toshiki Takahashi, Akiko Kuma, Hiroyuki Kawahara   +3 more
wiley   +1 more source

Data driven regulatory science

Pharmacoepidemiology and Drug Safety, 2015
Background: Drug regulatory science closely relates to pharmacoepidemiology, particularly where epidemiologic methods are used to derive empirical evidence on the outcomes and implications of drug regulation. Objectives: In this symposium, we will present the results from recent regulatory science studies on the functioning of post-marketing ...
De Bruin, Marie L., Ampadu, Haggar H., Hoekman, Jarno, Kurz, Xavier, Leufkens, Hubert G.M., Sekine, Shohko, Pan, Gerald Dal   +6 more
openaire   +2 more sources

Organizing the interface—Plasma membrane architecture and receptor dynamics in virus‐cell interactions

FEBS Letters, EarlyView.
Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley   +1 more source

European Regulatory Science and Regulatory Science Expert Training Project

Korean Journal of Clinical Pharmacy, 2021
Hocheol Shin, Jaehong Park, Jiwon Kim, Dajung Baek, Yun-ji Lee, Sun-Young Jung, Wonku Kang, Hahyung Kim, Young Wook Choi, Eunyoung Kim   +9 more
openaire   +2 more sources