Results 291 to 300 of about 2,996,073 (354)

Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer

Molecular Oncology, EarlyView.
PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta, Yang Song, Madeleine Ndahayo, Anirudh Saxena, Theresa Guo, Dylan Z. Kelley, Jessica Gore, Andrew Hennigan, Alexa Anderson, John C. Papadimitriou, Daria A. Gaykalova   +10 more
wiley   +1 more source

αTIGIT-IL2 achieves tumor regression by promoting tumor-infiltrating regulatory T cell fragility in mouse models. [PDF]

Nat Commun
Wang T, Xu Y, Zhang Z, Wu Y, Chen L, Zheng X, Peng H, Zou Q, Sun R, Ma H, Sun H, Tian Z, Zheng X.   +12 more
europepmc   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Regulatory T Cell Metabolism: A Promising Therapeutic Target for Cancer Treatment? [PDF]

Immune Netw
Kim J, Li J, Wei J, Lim SA.
europepmc   +1 more source

Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin

Molecular Oncology, EarlyView.
Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon, Dong Young Kim, Yuna Kim, Uk‐Il Kim, Jae‐Sung Kim   +4 more
wiley   +1 more source

Regulatory T cell therapy in autoimmune liver disease and transplantation. [PDF]

JHEP Rep
Fleming M, Sanchez-Fueyo A, Safinia N.
europepmc   +1 more source

Cotargeting TREM2 and IL2 pathways triggers multipronged anticancer immunity

Molecular Oncology, EarlyView.
Von Locquenghien et al. report that MiTE‐144, a triggering receptor expressed on myeloid cells 2 (TREM2) blocking antibody fused to interleukin‐2 (IL2) variant with tumour microenvironment restricted activation, demonstrates superior anticancer efficiency in a preclinical setting.
Isaure Vanmeerbeek, Jenny Sprooten, Abhishek D. Garg   +2 more
wiley   +1 more source

Intestinal Neutral Ceramidase Deficiency Triggers Regulatory T Cell Response via Gd3 to Protect the Host from Intestinal Inflammation. [PDF]

Adv Sci (Weinh)
Xu Z, Lei C, Sriwastva MK, Wang T, Tuohongerbieke A, Song X, Noud C, Derkson S, Tan Y, Dryden G, McClain CJ, Deng Z.   +11 more
europepmc   +1 more source

The Streptomyces Metabolite Thiostrepton Inhibits Regulatory T Cell Differentiation and Function to Boost Antitumor Immune Responses. [PDF]

Eur J Immunol
Silva L, Almeida L, Al-Naimi F, Nascimento DC, Lopez Krol A, Damasceno LEA, Echchannaoui H, Alves-Filho JC, Berod L, Sparwasser T.   +9 more
europepmc   +1 more source

LAG3 limits regulatory T cell proliferation in α-synuclein gut-to-brain transmission model. [PDF]

J Neuroinflammation
Kong WX, Zhang ZL, Li J, Zhu S, Li C, Dong XL, Gan TT, Hu D, Liang FC, Xu PY, Guo WY.   +10 more
europepmc   +1 more source