Results 131 to 140 of about 1,141,931 (248)

The frequency of regulatory T-cells in Hashimoto's thyroiditis and Graves' disease. [PDF]

Clin Exp Med
El Shabrawy RM, Ashour ZA, Ali FA, Hosny SS, Melek N, Okba A.   +5 more
europepmc   +1 more source

The balance between intrahepatic IL-17+ T cells and Foxp3+ regulatory T cells plays an important role in HBV-related end-stage liver disease [PDF]

, 2011
Yinghua Niu, Hongli Liu, Donglin Yin, Ruitian Yi, Tianyan Chen, Hong-an Xue, Shulin Zhang, Shumei Lin, Yingren Zhao   +8 more
openalex   +1 more source

Strong Expansion of Human Regulatory T Cells for Adoptive Cell Therapy Results in Epigenetic Changes Which May Impact Their Survival and Function

, 2021
Kristy Ou, Dania Hamo, Anne Schulze, Andy Roemhild, Daniel R. Kaiser, Gilles Gasparoni, Abdulrahman Salhab, Ghazaleh Zarrinrad, Leila Amini, Stephan Schlickeiser, Mathias Streitz, Jörn Walter, Hans‐Dieter Volk, Michael Schmueck‐Henneresse, Petra Reinke, Julia K. Polansky   +15 more
openalex   +1 more source

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

Why regulatory T cells love lactic acid. [PDF]

Mol Ther Methods Clin Dev
Chattopadhyay A, Ferreira LMR.
europepmc   +1 more source

Effects of cyclophosphamide and IL-2 on regulatory CD4+ T cell frequency and function in melanoma patients vaccinated with HLA-class I peptides: impact on the antigen-specific T cell response [PDF]

, 2013
Chiara Camisaschi, Paola Filipazzi, Marcella Tazzari, Chiara Casati, Valeria Beretta, Lorenzo Pilla, Roberto Patuzzo, Andrea Maurichi, Agata Cova, Michele Maio, Vanna Chiarion‐Sileni, Gabrina Tragni, Mario Santinami, Barbara Vergani, Antonello Villa, Emilio Berti, Ludmila Umansky, Philipp Beckhove, Viktor Umansky, Giorgio Parmiani, Licia Rivoltini, Chiara Castelli   +21 more
openalex   +1 more source

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

LAG-3⁺ Regulatory T Cells Suppress Effector Function of T Cells and Allow Their Proliferation Into Regulatory T Cells. [PDF]

Immunology
Dutta A, Miaw SC, Chen TC, Chang CS, Huang YL, Lin YC, Lin CY, Huang CT.   +7 more
europepmc   +1 more source

Effects of Desflurane and Sevoflurane anesthesia on regulatory T cells in patients undergoing living donor kidney transplantation: a randomized intervention trial [PDF]

, 2020
Arpa Chutipongtanate, Sasichol Prukviwat, Nutkridta Pongsakul, Supanart Srisala, Nakarin Kamanee, Nuttapon Arpornsujaritkun, Goragoch Gesprasert, Nopporn Apiwattanakul, Suradej Hongeng, Wichai Ittichaikulthol, V. Sumethkul, Somchai Chutipongtanate   +11 more
openalex   +1 more source

Predictors of response and rational combinations for the novel MCL‐1 inhibitor MIK665 in acute myeloid leukemia

Molecular Oncology, EarlyView.
This study characterizes the responses of primary acute myeloid leukemia (AML) patient samples to the MCL‐1 inhibitor MIK665. The results revealed that monocytic differentiation is associated with MIK665 sensitivity. Conversely, elevated ABCB1 expression is a potential biomarker of resistance to the treatment, which can be overcome by the combination ...
Joseph Saad, Rhiannon Newman, Elmira Khabusheva, Sofia Aakko, Eric Durand, Mahesh Tambe, Heikki Kuusanmäki, Alun Parsons, Juho J. Miettinen, Komal Kumar Javarappa, Ezgi June Olgac, Nemo Ikonen, Mika Kontro, Kimmo Porkka, Heiko Maacke, Janghee Woo, Ensar Halilovic, Caroline A. Heckman   +17 more
wiley   +1 more source