Results 171 to 180 of about 1,958,413 (325)

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

CD25+CD4+ Regulatory T Cells from the Peripheral Blood of Asymptomatic HIV-infected Individuals Regulate CD4+ and CD8+ HIV-specific T Cell Immune Responses In Vitro and Are Associated with Favorable Clinical Markers of Disease Status

, 2004
Audrey Kinter, Margaret Hennessey, Alicia Bell, Sarah Kern, Lin Yin, Marybeth Daucher, Maria Planta, Mary McGlaughlin, Robert W. Jackson, Steven F. Ziegler, Anthony S. Fauci   +10 more
openalex   +1 more source

Diet-induced dyslipidemia induces metabolic and migratory adaptations in regulatory T cells [PDF]

, 2020
Jacob Amersfoort, Frank H. Schaftenaar, Hidde Douna, Peter J. van Santbrink, Gijs H.M. van Puijvelde, Bram Slütter, Amanda C. Foks, Amy C. Harms, Estefanía Moreno-Gordaliza, Yanyan Wang, Thomas Hankemeier, Ilze Bot, Hongbo Chi, Johan Kuiper   +13 more
openalex   +1 more source

Regulatory T‐cell heterogeneity

Clinical & Translational Immunology, 2018
Ward-Hartstonge, KA, Vasanthakumar, A
openaire   +3 more sources

Predictors of response and rational combinations for the novel MCL‐1 inhibitor MIK665 in acute myeloid leukemia

Molecular Oncology, EarlyView.
This study characterizes the responses of primary acute myeloid leukemia (AML) patient samples to the MCL‐1 inhibitor MIK665. The results revealed that monocytic differentiation is associated with MIK665 sensitivity. Conversely, elevated ABCB1 expression is a potential biomarker of resistance to the treatment, which can be overcome by the combination ...
Joseph Saad, Rhiannon Newman, Elmira Khabusheva, Sofia Aakko, Eric Durand, Mahesh Tambe, Heikki Kuusanmäki, Alun Parsons, Juho J. Miettinen, Komal Kumar Javarappa, Ezgi June Olgac, Nemo Ikonen, Mika Kontro, Kimmo Porkka, Heiko Maacke, Janghee Woo, Ensar Halilovic, Caroline A. Heckman   +17 more
wiley   +1 more source

Dynamic changes in the regulatory T-cell heterogeneity and function by murine IL-2 mutein [PDF]

, 2020
Daniel Lu, Hao Wu, Ian Driver, Sarah Ingersoll, Sue J. Sohn, Songli Wang, Chi-Ming Li, Hyewon Phee   +7 more
openalex   +1 more source

Feasibility of a ctDNA multigenic panel for non‐small‐cell lung cancer early detection and disease surveillance

Molecular Oncology, EarlyView.
Plasma‐based detection of actionable mutations is a promising approach in lung cancer management. Analysis of ctDNA with a multigene NGS panel identified TP53, KRAS, and EGFR as the most frequently altered, with TP53 and KRAS in treatment‐naïve patients and TP53 and EGFR in previously treated patients.
Giovanna Maria Stanfoca Casagrande, Marcela de Oliveira Silva, Mariana Bisarro dos Reis, Rodrigo de Oliveira Cavagna, Luciane Sussuchi, Icaro Alves Pinto, Natalia Zampieri Pontes, Rodrigo Sampaio Chiarantano, Flavio Augusto Ferreira da Silva, Pedro de Marchi, Letícia Ferro Leal, Rui M. Reis   +11 more
wiley   +1 more source

Suppression of HIV-specific T cell activity by lymph node CD25⁺regulatory T cells from HIV-infected individuals

, 2007
Audrey Kinter, Jonathan P. McNally, Lindsey Riggin, Robert W. Jackson, Gregg Roby, Anthony S. Fauci   +5 more
openalex   +1 more source

Column-free methods for the fast and versatile isolation of highly purified, functional and expandable human regulatory T cell populations (LL3-3) [PDF]

, 2010
Andy I. Kokaji, Neil MacDonald, Maureen Fairhurst, Terry E. Thomas   +3 more
openalex   +1 more source

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source