Results 291 to 300 of about 1,958,413 (325)

Immunosuppressive mechanisms and therapeutic targeting of regulatory T cells in ovarian cancer. [PDF]

Front Immunol
Li J, Huang H, Xie R, Yang R, Wang H, Wan L.   +5 more
europepmc   +1 more source

Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin

Molecular Oncology, EarlyView.
Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon, Dong Young Kim, Yuna Kim, Uk‐Il Kim, Jae‐Sung Kim   +4 more
wiley   +1 more source

TRIP13 promotes the expansion and immunosuppression of CD4⁺Foxp3⁺ regulatory T cells by sustaining HAT1 stability. [PDF]

Cell Death Dis
He T, Zhao L, Feng CT, Zhao LY, Jing S, Yang H, Wang K, Ye S, Zhao Y, Yu Y, Fu Z, Chou CK, Chen X, Gao YJ.   +13 more
europepmc   +1 more source

Cotargeting TREM2 and IL2 pathways triggers multipronged anticancer immunity

Molecular Oncology, EarlyView.
Von Locquenghien et al. report that MiTE‐144, a triggering receptor expressed on myeloid cells 2 (TREM2) blocking antibody fused to interleukin‐2 (IL2) variant with tumour microenvironment restricted activation, demonstrates superior anticancer efficiency in a preclinical setting.
Isaure Vanmeerbeek, Jenny Sprooten, Abhishek D. Garg   +2 more
wiley   +1 more source

Regulatory T Cell Dysregulation in Vitiligo: A Meta-Analysis and Systematic Review of Immune Mechanisms and Therapeutic Perspectives

Gabriela Lerner, Maria Nikolaou, Corinne I. Stoffel, Eloi Schmauch, Thomas Kündig, Thierry Passeron, Julien Sénéschal, Nanja Van Geel, Ulrike Held, Antonios G A Kolios   +9 more
openalex   +1 more source

Assessment and Characterization of Induced Alloantigen-Specific Regulatory T Cells Obtained by the Inhibition of CDK8/19 with the AS2863619 Compound. [PDF]

Int J Mol Sci
Bulygin A, Fisher M, Kurilin V, Alrhmoun S, Perik-Zavodskii R, Perik-Zavodskaia O, Volynets M, Shkaruba N, Obleukhova I, Khantakova J, Golikova E, Silkov A, Sennikov S.   +12 more
europepmc   +1 more source

Reduced circulating regulatory T cells in primary Sjögren's syndrome: the contribution of enhanced apoptosis and impaired survival. [PDF]

Front Immunol
Wang Y, Jia Y, Guo H, Feng M, Qin Y, Liang Z, Zhao X, Gao C, Luo J.   +8 more
europepmc   +1 more source

Intravenous Immunoglobulin Elevates Regulatory T Cells in Guillain-Barré Syndrome: A Potential Biomarker of Therapeutic Response. [PDF]

J Peripher Nerv Syst
Jahan I, Ahmed R, Ahmed J, Afsar NA, Biswas PP, Khurshid S, Mohammad QD, Endtz HP, Huizinga R, Jacobs BC, Islam Z.   +10 more
europepmc   +1 more source

Infusion of Induced Regulatory T Cells Alleviates Atherosclerosis by Reducing Pathological Macrophage-Like Vascular Smooth Muscle Cells. [PDF]

MedComm (2020)
Zhang X, Chen Y, Ling Y, Wu L, Liu D, Wang L, Liu Y, Shi G, Zhou B, Hao B, Zheng Z, Yu S, Wang M, Zhao J, Zeng D, Wang J, Lu Y, Tao J, Xia W, Zheng SG, Qian X.   +20 more
europepmc   +1 more source

Neonatal regulatory T cells persist into adulthood across multiple tissues with high enrichment in the skin. [PDF]

Sci Adv
Hilaire M, Mimoun A, Cagnet L, Villette R, Roubanis A, Sentenac H, Salomon BL.   +6 more
europepmc   +1 more source