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T regulatory cells turn on T regulatory cells
Blood, 2009In this issue of Blood , Miao and colleagues demonstrate that Tregs from a FoxP3 transgenic mouse injected with a normally immunogenic FVIII plasmid not only suppress the response to FVIII but also may “turn on” host Tregs upon adoptive transfer.
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Seminars in Immunopathology, 2016
Our initial understanding of immune-regulatory cells was based on the discovery of suppressor cells that assure peripheral T-cell tolerance and promote immune homeostasis. Research has particularly focused on the importance of regulatory T cells (Tregs) for immune modulation, e.g.
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Our initial understanding of immune-regulatory cells was based on the discovery of suppressor cells that assure peripheral T-cell tolerance and promote immune homeostasis. Research has particularly focused on the importance of regulatory T cells (Tregs) for immune modulation, e.g.
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2016
Regulatory T cells (Tregs) are CD4+ T cells that inhibit autoreactive effector T cells to suppress antitumor immunity. Many anticancer therapeutics have limited efficacy, and it is thought that Tregs may, in part, be one of the reasons. From this viewpoint, Tregs may be a therapeutic target for cancer immunotherapy.
M. Monteiro +4 more
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Regulatory T cells (Tregs) are CD4+ T cells that inhibit autoreactive effector T cells to suppress antitumor immunity. Many anticancer therapeutics have limited efficacy, and it is thought that Tregs may, in part, be one of the reasons. From this viewpoint, Tregs may be a therapeutic target for cancer immunotherapy.
M. Monteiro +4 more
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2018
The tumor microenvironment consists of numerous and diverse immune cells many of which act to suppress the immune system response against cancer cells. Regulatory T cells (Tregs) perform a key role in mediating this immunosuppressive response via a variety of mechanisms.
Vaia Florou, Breelyn A. Wilky
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The tumor microenvironment consists of numerous and diverse immune cells many of which act to suppress the immune system response against cancer cells. Regulatory T cells (Tregs) perform a key role in mediating this immunosuppressive response via a variety of mechanisms.
Vaia Florou, Breelyn A. Wilky
openaire +1 more source