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T regulatory cells turn on T regulatory cells
Blood, 2009In this issue of Blood , Miao and colleagues demonstrate that Tregs from a FoxP3 transgenic mouse injected with a normally immunogenic FVIII plasmid not only suppress the response to FVIII but also may “turn on” host Tregs upon adoptive transfer.
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Targeted Oncology, 2012
Cancers express tumor-associated antigens that should elicit immune response to antagonize the tumor growth, but spontaneous immune rejection of established cancer is rare, suggesting an immunosuppressive environment hindering host antitumor immunity.
Ménétrier-Caux, Christine +5 more
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Cancers express tumor-associated antigens that should elicit immune response to antagonize the tumor growth, but spontaneous immune rejection of established cancer is rare, suggesting an immunosuppressive environment hindering host antitumor immunity.
Ménétrier-Caux, Christine +5 more
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Regulatory T cells as therapeutic cells
Current Opinion in Organ Transplantation, 2008Although a plethora of data indicate the importance of regulatory T cells (Tregs) in experimental and clinical transplantation, are we any closer to seeing these cells as therapeutic tools in the clinic? This review discusses the functional and practical aspects of using CD4+CD25hiFoxp3+ Tregs as cellular therapeutic products in clinical ...
Sagoo, Pervinder +2 more
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Annales de dermatologie et de venereologie, 2007
International ...
Aubin, François, Saas, Philippe
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International ...
Aubin, François, Saas, Philippe
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2015
The current concept of the pathogenesis of obesity relates to the inflammation caused by excess of adipose tissue. Regulatory T cells accumulated in visceral adipose tissue (VAT-resident Tregs) are also involved in this pathogenesis. In the present paper the mechanisms responsible for alterations in the number and function of VAT-resident Tregs T in ...
Anna Kucharska +2 more
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The current concept of the pathogenesis of obesity relates to the inflammation caused by excess of adipose tissue. Regulatory T cells accumulated in visceral adipose tissue (VAT-resident Tregs) are also involved in this pathogenesis. In the present paper the mechanisms responsible for alterations in the number and function of VAT-resident Tregs T in ...
Anna Kucharska +2 more
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Annual Review of Immunology, 2020
Foxp3-expressing CD4+regulatory T (Treg) cells play key roles in the prevention of autoimmunity and the maintenance of immune homeostasis and represent a major barrier to the induction of robust antitumor immune responses. Thus, a clear understanding of the mechanisms coordinating Treg cell differentiation is crucial for understanding numerous facets ...
Peter A. Savage +2 more
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Foxp3-expressing CD4+regulatory T (Treg) cells play key roles in the prevention of autoimmunity and the maintenance of immune homeostasis and represent a major barrier to the induction of robust antitumor immune responses. Thus, a clear understanding of the mechanisms coordinating Treg cell differentiation is crucial for understanding numerous facets ...
Peter A. Savage +2 more
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Current Opinion in Organ Transplantation, 2003
Having been a taboo subject for many years, dedicated regulatory T cells are now center stage. To the transplantation immunologist, this should not come as a surprise, given that transferable T-cell tolerance has remained a robust phenomenon over the past 2 decades.
Marina I. Garin, Robert I. Lechler
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Having been a taboo subject for many years, dedicated regulatory T cells are now center stage. To the transplantation immunologist, this should not come as a surprise, given that transferable T-cell tolerance has remained a robust phenomenon over the past 2 decades.
Marina I. Garin, Robert I. Lechler
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Regulatory T-Cells and Autoimmunity
Journal of Surgical Research, 2006Approximately 20% of the population is affected by autoimmune or inflammatory diseases mediated by an abnormal immune response. A characteristic feature of autoimmune disease is the selective targeting of a single cell type, organ or tissue by certain populations of autoreactive T-cells.
Niamh Ni Choileain, Henry Paul Redmond
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Immunological Reviews, 2016
SummaryPathogen exposure elicits production of high‐affinity antibodies stimulated by T follicular helper (Tfh) cells in the germinal center reaction. Tfh cells provide both costimulation and stimulatory cytokines to B cells to facilitate affinity maturation, class switch recombination, and plasma cell differentiation within the germinal center.
Arlene H. Sharpe +3 more
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SummaryPathogen exposure elicits production of high‐affinity antibodies stimulated by T follicular helper (Tfh) cells in the germinal center reaction. Tfh cells provide both costimulation and stimulatory cytokines to B cells to facilitate affinity maturation, class switch recombination, and plasma cell differentiation within the germinal center.
Arlene H. Sharpe +3 more
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Current Opinion in Immunology, 2007
Increasing evidence indicates that T regulatory (Treg) cells have the potent ability to suppress host immune responses, thus preventing autoimmune diseases. However, recent studies demonstrate that tumor cells can recruit these Treg cells to inhibit antitumor immunity in the tumor microenvironment, thus limiting the efficiency of cancer immunotherapy ...
Helen Yicheng Wang, Rongfu Wang
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Increasing evidence indicates that T regulatory (Treg) cells have the potent ability to suppress host immune responses, thus preventing autoimmune diseases. However, recent studies demonstrate that tumor cells can recruit these Treg cells to inhibit antitumor immunity in the tumor microenvironment, thus limiting the efficiency of cancer immunotherapy ...
Helen Yicheng Wang, Rongfu Wang
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