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The role of regulatory t lymphocytes in asthma pathogenesis [PDF]

Current Allergy and Asthma Reports, 2005
Several subtypes of regulatory or suppressive T cells have been described that can prevent activation of effector T cells in vitro and in vivo in animal models. Recent evidence suggests a deficit in suppressive activity of both CD4(+)CD25(+) regulatory T cells, and interleukin (IL)-10 producing regulatory T cells may play a role in development of ...
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Regulatory T cells in chronic lymphocytic leukemia [PDF]

Comparative Clinical Pathology, 2014
Controversial results concerning the prognostic value of the regulatory T (Treg) cell percentage in peripheral blood of chronic lymphocytic leukemia (CLL) patients have been reported in the previous studies. This study aimed to estimate the prognostic relevance of Treg cells in untreated CLL patients at diagnosis.
Lamiaa Ebrahim, Nadia El Menshawy, Salah Aref, Emad Azmy, Hazem Hakim, Tawfik Elkhodary   +5 more
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Regulatory Factors Produced by Lymphocytes

The Journal of Immunology, 1976
Abstract Supernatant fluids of mitogen-activated human tonsil lymphocytes contain large amounts of a factor toxic to mouse L cells. This substance, with a m.w. of 80,000 ±5,000 daltons, is called α-lymphotoxin (α-LT), to differentiate it from another toxin elaborated by mitogen-activated human blood lymphocytes, called β-lymphotoxin (β ...
Sheng-Chung Lee, Zoltan J. Lucas
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Regulatory T Lymphocytes Distribution And Eosinophilic Gastroenteropathy [PDF]

Journal of Allergy and Clinical Immunology, 2007
T. Yan, C. Barone, Stephen J. McGeady, P. Vannelli   +3 more
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T-regulatory lymphocytes and chronic viral hepatitis

Expert Opinion on Biological Therapy, 2007
Both hepatitis B virus (HBV) and hepatitis C virus (HCV) can cause persistent viral infection in humans. Chronic infection is associated with a risk of cirrhosis and hepatocellular carcinoma. The cause of chronic infection is unknown. A large body of evidence suggests that a failure of the adaptive immune response is critical in the establishment of ...
Simon M. Rushbrook, Graeme J.M. Alexander, Matthew Hoare   +2 more
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The regulatory network that controls the differentiation of T lymphocytes

Biosystems, 2013
There is a vast amount of molecular information regarding the differentiation of T lymphocytes, in particular regarding in vitro experimental treatments that modify their differentiation process. This publicly available information was used to infer the regulatory network that controls the differentiation of T lymphocytes into CD4(+) and CD8(+) cells ...
Luis Mendoza, Pablo Martínez-Sosa
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Role of Regulatory T Lymphocytes in Health and Disease [PDF]

, 2020
T cells are conventionally categorized into two basic types, viz., CD4+ helper and CD8+ cytotoxic T cells. CD4+ T cells were known to “help” in the activation and differentiation of various immune cells such as NK cells, macrophages, and dendritic cells, whereas CD8+ T cells were known to kill foreign antigens.
Niti Shokeen, Zaffar Azam, Ayaan Ahmad, Asha Bhardwaj, Leena Sapra, Chaman Saini, Rupesh K. Srivastava   +6 more
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Development of Thymic Regulatory T Lymphocytes

2019
A healthy immune system should maintain a balance between the ability to respond to infectious agents and tumor cells at the same time that sustains self-tolerance. For this purpose, the immune system must be capable of restraining foreign antigens, stopping the immune response after the resolution of a problem and blocking autoreactivity of immune ...
Arnon Dias Jurberg, Vinicius Cotta-de-Almeida, João Ramalho Ortigão-Farias, Rafaella Ferreira-Reis, Larissa Vasconcelos-Fontes   +4 more
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Regulatory substances produced by lymphocytes—IV

Immunochemistry, 1975
Abstract Rat lymphotoxin (LT), a soluble mediator which kills L cells (mouse fibroblasts) within 48 hr, was partially purified by conventional protein fractionation procedures from the culture supernatants of rat lymph node cells stimulated with ovalbumin in vivo and rechallenged with the same antigen in vitro.
Yuziro Namba, Byron H. Waksman
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Regulatory Role of T Lymphocytes in Atopic Dermatitis

2008
Eczema does not occur in the absence of T cells. Here we provide an overview on the regulatory impact which T cells have on the establishment and maintenance of atopic dermatitis. Particularly, we outline the role of different T-helper cell subsets (i.e.
Thomas Werfel, Miriam Wittmann
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