Optimal Control of Tuberculosis: A Review
We review the optimal control of systems modeling the dynamics of tuberculosis. Time dependent control functions are introduced in the mathematical models, representing strategies for the improvement of the treatment and cure of active infectious and/or ...
Silva, Cristiana J.+1 more
core +1 more source
The therapeutic efficacy and macrofilaricidal activity of doxycycline for the treatment of river blindness [PDF]
Background. Onchocerca volvulus and lymphatic filariae, causing river blindness and elephantiasis, depend on endosymbiotic Wolbachia bacteria for growth, development, fertility, and survival.
Achim Hoerauf+43 more
core +1 more source
Complications of Resection Arthroplasty in Two-Stage Revision for the Treatment of Periprosthetic Hip Joint Infection [PDF]
Little data is available regarding complications associated with resection arthroplasty in the treatment of hip periprosthetic joint infection (PJI). We assessed complications during and after two-stage revision using resection arthroplasty.
Perka, Carsten+5 more
core +1 more source
Locally self-organized quasi-critical percolation in a multiple disease model [PDF]
Diseases emerge, persist and vanish in an ongoing battle for available hosts. Hosts, on the other hand, defend themselves by developing immunity that limits the ability of pathogens to reinfect them. We here explore a multi-disease system with emphasis on mutual exclusion.
arxiv +1 more source
Prioritization of HCV treatment in the direct-acting antiviral era: an economic evaluation [PDF]
BACKGROUND & AIMS: We determined the optimal HCV treatment prioritization strategy for interferon-free (IFN-free) HCV direct-acting antivirals (DAAs) by disease stage and risk status incorporating treatment of people who inject drugs (PWID).
Afdhal+51 more
core +2 more sources
Critical behavior of the SIS epidemic model with time-dependent infection rate [PDF]
In this work we study a modified Susceptible-Infected-Susceptible (SIS) model in which the infection rate $\lambda$ decays exponentially with the number of reinfections $n$, saturating after $n=l$. We find a critical decaying rate $\epsilon_{c}(l)$ above which a finite fraction of the population becomes permanently infected.
arxiv +1 more source
Discrete Poisson hardcore 1D model and reinfections [PDF]
We suggest a new hardcore Poisson-type distribution for Young diagrams with the row lengths from some finite list. A discrete variant of the time-ordered Mat\'{e}rn II process in 1D is employed. This approach is related to that based on the interlacing sequences due to Kerov and others, but we restrict the number of rows.
arxiv
Estimates of the reproduction numbers of Spanish influenza using morbidity data.
BACKGROUND: There have been several studies of the transmissibility of the 1918 (Spanish) influenza virus, which has attributed to >20 million deaths.
Mangtani, Punam+2 more
core +1 more source
Human Schistosome Infection and Allergic Sensitisation [PDF]
Several field studies have reported an inverse relationship between the prevalence of helminth infections and that of allergic sensitisation/atopy. Recent studies show that immune responses induced by helminth parasites are, to an extent, comparable to ...
Mutapi, Francisca+2 more
core +3 more sources
Growth of Cowdria ruminantium, the causative agent of heartwater, in a tick cell line [PDF]
The tick-borne rickettsia Cowdria ruminantium has been propagated continuously for over 500 days in the Ixodes scapularis tick cell line IDE8 by using the Gardel isolate from bovine endothelial cells as an inoculum.
Bell-Sakyi, Lesley+3 more
core +2 more sources