Results 111 to 120 of about 1,816,503 (312)

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

open access: yesFEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li   +2 more
wiley   +1 more source

Strongly Vertex-Reinforced-Random-Walk on the complete graph

open access: yes, 2013
We study Vertex-Reinforced-Random-Walk on the complete graph with weights of the form $w(n)=n^\alpha$, with $\alpha>1$. Unlike for the Edge-Reinforced-Random-Walk, which in this case localizes a.s.
Benaïm, Michel   +2 more
core  

Cell wall target fragment discovery using a low‐cost, minimal fragment library

open access: yesFEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan   +5 more
wiley   +1 more source

Reinforced Concrete [PDF]

open access: yesProceedings of the Institution of Mechanical Engineers, 1909
n ...
openaire   +2 more sources

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

open access: yesFEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee   +3 more
wiley   +1 more source

Improvement of the mathematical model of the diagram of deformation of the compressed composite steel and concrete structures

open access: yesMATEC Web of Conferences, 2017
The mathematical model of the stress-strain ratio of compressed concrete at elevated temperatures for composite structures described in Eurocode EN 1994-1-2:2005 Eurocode 4 divided in two stages: Stage 1 - represents the ascending branch and is defined ...
Fomin Stanislav   +4 more
doaj   +1 more source

Fuselage structure using advanced technology fiber reinforced composites [PDF]

open access: yes, 1982
A fuselage structure is described in which the skin is comprised of layers of a matrix fiber reinforced composite, with the stringers reinforced with the same composite material.
Robinson, R. K., Tomlinson, H. M.
core   +1 more source

Structural biology of ferritin nanocages

open access: yesFEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

open access: yesFEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Effect of Polylactic Acid (PLA) as Reinforcement for Jackfruit Seed Starch-Based Degradable Plastic

open access: yesEngineering Proceedings
Synthetic plastics harm the environment, so finding better materials is important. Researchers have studied PLA and starch to replace non-degradable petrochemicals. This research uses jackfruit seed starch and PLA to make degradable plastics. The tensile
Rozanna Dewi, Novi Sylvia, Medyan Riza
doaj   +1 more source

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