Results 141 to 150 of about 646,807 (289)

Engineering Osteoimmune Responses with Functionalized Orthopedic Implants for Post‐Operative Osteosarcoma Treatment

open access: yesAdvanced Science, EarlyView.
Osteosarcoma is the most common primary bone tumor with limited treatment options and a terrible prognosis. This review provides a comprehensive summary of the recent development of osteoimmunomodulatory implants for post‐operative osteosarcoma treatment, of which the potential utility in evoking durable anti‐osteosarcoma immunity and accelerating bone
Yilong Dong   +6 more
wiley   +1 more source

CELLama: Foundation Model for Single Cell and Spatial Transcriptomics by Cell Embedding Leveraging Language Model Abilities

open access: yesAdvanced Science, EarlyView.
CELLama is created, a framework that harnesses language models to convert cellular data into “sentences” that represent gene expression and metadata, enabling a universal embedding of cells. Unlike most single‐cell foundation models, CELLama supports scalable analysis and offers flexible applications including spatial transcriptomics.
Jeongbin Park   +7 more
wiley   +1 more source

The Effects of Pattern Loadings on Reinforced Concrete Floor Slabs [PDF]

open access: yes, 1963
Reinforced Concrete Reserach CouncilOffice of the Chief of Engineers, U.S. Army.General Services Administration, Public Buildings ServiceHeadquarters, U.S. Air Force, Directorate of Civil Engineering.U.S. Navy, Engineering Division.
Jirsa, J.O., Siess, C.P., Sozen, M.A.
core  

Targeting Fibrotic Scarring by Mechanoregulation of Il11ra1+/Itga11+ Fibroblast Patterning Promotes Axon Growth after Spinal Cord Injury

open access: yesAdvanced Science, EarlyView.
This study demonstrates that a hydrogel with mechanical properties matching the spinal cord directs fibroblast alignment, reshaping fibrotic scars into parallel matrices. A specific fibroblast subset mediates extracellular matrix remodeling through mechanotransduction, promoting axonal regeneration and neural reconnections, revealing potential ...
Longyou Xiao   +11 more
wiley   +1 more source

Design philosophy issues of fiber reinforced polymer reinforced concrete structures

open access: yes, 2002
The conventional design philosophy for reinforced concrete (RC) relies heavily on the ductile properties of steel. These ductile properties are used as a "fuse" and conceal the large uncertainty in the determination of modes of failure caused ...
Guadagnini, M.   +2 more
core  

Knowledge Graph for Methane Selective Conversion: Revisiting and Predicting Product Selectivity and Methane Conversion

open access: yesAdvanced Science, EarlyView.
With the help of large language models, deep neural network learning, and kinetic calculation, a knowledge graph prediction of prior research in methane conversion is conducted. This knowledge graph provides a comprehensive understanding of the relationships among catalyst materials, catalytic performance, and reaction conditions, providing guidance ...
Boyu Xu   +11 more
wiley   +1 more source

Design Essentials in Earthquake Resistant Buildings [Book Review] [PDF]

open access: yes, 1971
This book was prepared by a committee of 25 Japanese earthquake engineers with the objective of providing a comprehensive account of the present status of earthquake-resistant construction methods. The 17 chapters comprising the book are: 1.
Housner, George W.
core  

Hysteresis Behavior of RC Beam–Column Joints of Existing Substandard RC Structures Subjected to Seismic Loading–Experimental and Analytical Investigation

open access: yesBuildings
Four exterior reinforced concrete beam–column joint subassemblages with poor reinforcement details and low-quality materials were constructed and subjected to cyclic lateral deformations under constant axial loading of the columns.
George Kalogeropoulos   +2 more
doaj   +1 more source

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