Results 181 to 190 of about 103,708 (231)

PD‐1 Inhibits CD4+ TRM‐Mediated cDC1 Mobilization via Suppressing JAML in Human NSCLC

Advanced Science, EarlyView.
CD4+ tissue‐resident memory T cells (TRMs) in non‐small cell lung cancer recruit conventional type 1 dendritic cells via XCL1‐XCR1 signaling, orchestrating antitumor immunity. The costimulatory molecule JAML is essential for this process. PD‐1 blockade restores JAML expression and cDC1 mobilization, while JAML agonists synergize with anti‐PD‐1 therapy,
Zheyu Shao, Qinyuan Liu, Zhongwei Xin, Zhiyao Zhou, Mingjie Lin, Di Chen, Zhixing Hao, Yongyuan Chen, Wenxuan Wu, Shuyang Zhang, Xiaoke Chen, Xia Xu, Jinfan Li, Wei Lin, Yuhao Lu, Dang Wu, Pin Wu   +16 more
wiley   +1 more source

Reference Point-Dependent Reinforcement Learning in Humans and Rats

Palminteri S, Ferguson L, Soukupova M, Bouret S, Parkes S.   +4 more
europepmc   +1 more source

Gut Microbiota‐Derived Anandamide Mediates the Therapeutic Effects of Urolithin A on Alcohol‐Induced Cognitive and Social Dysfunction via CB1R‐DRD2‐RAP1 Signaling Axis

Advanced Science, EarlyView.
This study reveals that Urolithin A (UA) counteracts alcohol‐induced cognitive and social dysfunction (AICSD) via a gut microbiome‐dependent mechanism. UA‐enriched Bacteroids sartorii and Parabacteroids distasonis elevate anandamide (AEA), which activates the CB1R‐DRD2‐Rap1 signaling cascade to drive synaptic repair and reduce neuroinflammation ...
Hongbo Zhang, Zibin Li, Yao Xiao, Ji Bian, Caian He, Chao Liu, Lan Gong, Lin Han, Zhigang Liu, Min Wang   +9 more
wiley   +1 more source

Smartphone App Using Reinforcement Learning for Obesity: Single-Arm Feasibility Study.

JMIR Hum Factors
Kurisu K, Yamamoto Y, Aoyama T, Yamauchi T, Yoshiuchi K.   +4 more
europepmc   +1 more source

rECMOmender: Reinforcement Learning for Decision Support in Venovenous Extracorporeal Membrane Oxygenation Management. [PDF]

Crit Care Explor
Song J, Dave SB, Yang Y, Foote H, Moore R, Upadhyaya P, Lima L, Creel C, Xu P, Jabaley CS, Kamaleswaran R.   +10 more
europepmc   +1 more source

Divergent Responses of Bacterial Communities to Permafrost Degradation and Their Associations With Carbon Across Vertical Profiles

Advanced Science, EarlyView.
Bacterial α‐diversity decreases, but stochasticity and community stability increase across the 15 m‐depth vertical profiles and along the degraded gradient within the active layer. The abundance and interaction of core taxa mainly control community stability in the active and permafrost layers, respectively.
Shengyun Chen, Yuzheng Gu, Ali Bahadur, Enyan Liu, Tonghua Wu, Xiaofan Zhu, Yuanqiang Zou, Hewei Liang, Peijie Wei, Linwei Wu, Qingbai Wu, Peizhi Yang, Hongyan Yu, Yunfeng Yang   +13 more
wiley   +1 more source

Estrogen modulates reward prediction errors and reinforcement learning. [PDF]

Nat Neurosci
Golden CEM, Martin AC, Kaur D, Mah A, Levy DH, Yamaguchi T, Lasek AW, Lin D, Aoki C, Constantinople CM.   +9 more
europepmc   +1 more source

Foundation Model‐Enabled Multimodal Deep Learning for Prognostic Prediction in Colorectal Cancer with Incomplete Modalities: A Multi‐Institutional Retrospective Study

Advanced Science, EarlyView.
FLARE, a multimodal AI framework, combines pathology slides, radiology scans, and clinical reports to predict colorectal cancer outcomes, even when some tests are missing. Evaluated retrospectively in 1679 patients from four medical centers, it consistently achieved the best prognostic accuracy and clearly separated high‐ and low‐risk groups.
Linhao Qu, Chengsheng Zhang, Yingyong Hou, Feng Tang, Weiqi Sheng, Dan Huang, Zhijian Song   +6 more
wiley   +1 more source

Deep Reinforcement Learning for Sustainable Urban Mobility: A Bibliometric and Empirical Review. [PDF]

Sensors (Basel)
Jamal S, Siddiqui F, Alam MA, Ayman-Mursaleen M, Zafar S, Naaz S.   +5 more
europepmc   +1 more source

Categorization and Reinforcement Learning: State Identification in Reinforcement Learning and Network Reinforcement Learning

, 2007
Veksler, Vladislav D., Gray, Wayne D., Schoelles, Micheal J.   +2 more
openaire   +1 more source