Results 91 to 100 of about 293,378 (334)

Mitochondrial CISD1 Modulates Microglial Metabolic Reprogramming to Drive Stress Susceptibility in Mice

Advanced Science, EarlyView.
CDGSH iron sulfur domain 1 (CISD1) mitigates oxidative stress by promoting NADH oxidation and Coenzyme Q (CoQ) reduction. Under chronic stress, elevated CISD1 expression in microglia enhances NAD⁺ production, thereby increasing GAPDH activity and glycolytic flux, while reducing ATP synthesis by inhibiting proton transfer from mitochondrial complexes I ...
Wanting Dong, Duo Liu, Songsen Fu, Jiaming Zhang, Xi Chen, Songqiang Huang   +5 more
wiley   +1 more source

Suboptimal Choice Behaviour across Different Reinforcement Probabilities [PDF]

, 2015
Six adult roosters’ choice behaviour was investigated across a series of five experimental conditions and a series of replication of the same five experimental conditions. Stagner and Zentall (2010) found that pigeons prefer to choose an alternative with
Yang, Le
core   +1 more source

Parabiosis, Assembloids, Organoids (PAO)

Advanced Science, EarlyView.
This review evaluates parabiosis, organoids, and assembloids as complementary disease models spanning systemic, organ, and multi‐organ levels. It highlights their construction strategies, applications, and current limitations, while emphasizing their integration with frontier technologies such as artificial intelligence, organ‐on‐a‐chip, CRISPR, and ...
Yang Hong, Lavonda Li, Lijie Yan, Long Bai, Jiacan Su, Xingcai Zhang   +5 more
wiley   +1 more source

It's worse than you thought : the feedback negativity and violations of reward prediction in gambling tasks

, 2007
The reinforcement learning theory suggests that the feedback negativity should be larger when feedback is unexpected. Two recent studies found, however, that the feedback negativity was unaffected by outcome probability.
Hajcak, Greg, Holroyd, Clay, Moser, Jason S., Simons, Robert F.   +3 more
core   +1 more source

The Mitochondrial Guardian α‐Amyrin Mitigates Alzheimer's Disease Pathology via Modulation of the DLK‐SARM1‐ULK1 Axis

Advanced Science, EarlyView.
Dietary habits play a key role in chronic diseases, and higher annual consumption of fruit and vegetable may lower risk of dementia. Artificial intelligence predicts the lipid‐like compound α‐Amyrin (αA) from plants with edible peels as a drug candidate against Alzheimer's disease.
Shu‐Qin Cao, Juan Ignacio Jiménez‐Loygorri, Yunguang Qiu, You Jung Kang, Khanh Van Do, Annabel E. Smith, Junjie Huang, Jun‐ping Pan, Lipeng Mao, Ang Li, Hangge Yang, Yahyah Aman, Maria Jose Donate Lagartos, Sofie Hindkjær Lautrup, Anbin Chen, Kristina Xiao Liang, Hailong Zhang, Juan Yi, Xurui Jin, Tin Cho Cheung, Olympia Apokotou, Florentia Papastefanaki, Rebecca Matsas, William A. McEwan, Feixiong Cheng, Hansang Cho, Guobing Chen, Huanxing Su, Konstantinos Palikaras, Oscar Junhong Luo, Qian Hua Zhao, Ding Ding, Cornelia van Duijn, Nektarios Tavernarakis, Patricia Boya, Tewin Tencomnao, Evandro F. Fang   +36 more
wiley   +1 more source

Haste or Speed? Alterations in the Impact of Incentive Cues on Task Performance in Remitted and Depressed Patients With Bipolar Disorder

Frontiers in Psychiatry, 2018
A variety of evidence suggests that bipolar disorder is associated with disruptions of reward related processes, although the properties, and scope of these changes are not well understood.
Henry W. Chase, Jay C. Fournier, Haris Aslam, Richelle Stiffler, Jorge R. Almeida, Barbara J. Sahakian, Mary L. Phillips   +6 more
doaj   +1 more source

Effects of Motivation on Test Performance of First Year Covenant University Students [PDF]

, 2012
This study examined the effect of motivation on test performance of first year Covenant University students, Ota, Ogun State. The study adopted pre-test, post-test experimental design.
Adekeye, Olujide A, Ademuwagun, Olufunke E, Aremu, Oluyori   +2 more
core   +1 more source

Light Therapy Alleviates Addiction‐Related Symptoms and Reshapes Habenula and Midbrain Pathways

Advanced Science, EarlyView.
This study investigates light therapy for treating Internet Gaming Disorder (IGD). Functional MRI (fMRI) data reveal that light therapy enhances brain connectivity, particularly between the habenula and the medial orbitofrontal cortex (mOFC). These changes are associated with reduced withdrawal symptoms and addiction severity, highlighting the ...
Jinhui Li, Huiyang Huang, Cunhao Hu, Xuan Zhang, Song Lin, Xiaodan Huang, Ti‐fei Yuan, Kwok‐Fai So, Lu Huang, Chaoran Ren, Qian Tao   +10 more
wiley   +1 more source

ChatGPT: perspectives from human–computer interaction and psychology

Frontiers in Artificial Intelligence
The release of GPT-4 has garnered widespread attention across various fields, signaling the impending widespread adoption and application of Large Language Models (LLMs). However, previous research has predominantly focused on the technical principles of
Jiaxi Liu
doaj   +1 more source

Direct Observation in an Outpatient Clinic: A New Easier Tool

MedEdPORTAL, 2010
Direct observation of residents is a key assessment tool for competency in (1) patient care, (2) professionalism, and (3) communication. Although several observation tools exist, most do not have known validity and reliability.
Rebecca Swan, Joseph Gigante
doaj   +1 more source