Frontiers in Behavioral Neuroscience, 2014 We previously reported that, in male, Long Evans rats, instrumental lever pressing that had been reinforced during limited training under a variable interval (VI) schedule by oral self-administration of a 10% sucrose/10% ethanol (10S10E) solution was ...
Regina A. Mangieri +2 more
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Balancing Project Schedule, Cost, and Value under Uncertainty: A Reinforcement Learning Approach
Algorithms, 2023 Industrial projects are plagued by uncertainties, often resulting in both time and cost overruns. This research introduces an innovative approach, employing Reinforcement Learning (RL), to address three distinct project management challenges within a ...
Claudio Szwarcfiter +2 more
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Nucleus accumbens core lesions retard instrumental learning and performance with delayed reinforcement in the rat. [PDF]
, 2005 BACKGROUND: Delays between actions and their outcomes severely hinder reinforcement learning systems, but little is known of the neural mechanism by which animals overcome this problem and bridge such delays.
Cardinal, Rudolf N, Cheung, Timothy HC
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Selective disruption of stimulus-reward learning in glutamate receptor gria 1 knockout mice. [PDF]
, 2003 Glutamatergic neurotransmission via AMPA receptors has been an important focus of studies investigating neuronal plasticity. AMPA receptor glutamate receptor 1 (GluR1) subunits play a critical role in long-term potentiation (LTP).
Mead, Andy N, Stephens, David N
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Modeling the violation of reward maximization and invariance in reinforcement schedules.
PLoS Computational Biology, 2008 It is often assumed that animals and people adjust their behavior to maximize reward acquisition. In visually cued reinforcement schedules, monkeys make errors in trials that are not immediately rewarded, despite having to repeat error trials.
Giancarlo La Camera, Barry J Richmond
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Hypocretin-1 receptors regulate the reinforcing and reward-enhancing effects of cocaine: pharmacological and behavioral genetics evidence. [PDF]
, 2012 Considerable evidence suggests that transmission at hypocretin-1 (orexin-1) receptors (Hcrt-R1) plays an important role in the reinstatement of extinguished cocaine-seeking behaviors in rodents.
Fowler, Christie D +3 more
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Adolescent methylphenidate treatment differentially alters adult impulsivity and hyperactivity in the Spontaneously Hypertensive Rat model of ADHD [PDF]
, 2016 Impulsivity and hyperactivity are two facets of attention deficit/hyperactivity disorder (ADHD). Impulsivity is expressed as reduced response inhibition capacity, an executive control mechanism that prevents premature execution of an intermittently ...
Bardo, M. T. +3 more
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Brain Sciences, 2018 Lower impulse control is a known risk factor for drug abuse vulnerability. Chronic experience with illicit drugs is suggested to enhance impulsivity and thereby perpetuate addiction.
Sucharita S. Somkuwar +6 more
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Effects of neonatal NMDA-subtype glutamate receptor blockade on behavior of adult male rats
Учёные записки Санкт-Петербургского государственного медицинского университета им. Акад. И.П. Павлова, 2022 Introduction. Cognitive impairments are important components of the clinical picture of many neuropsychiatric disorders, and are in dire need of evidence-based pharmacotherapeutic approaches.The objective was to test a model of delayed cognitive ...
I. M. Sukhanov +3 more
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Deficient reinforcement learning in medial frontal cortex as a model of dopamine-related motivational deficits in ADHD [PDF]
, 2013 A
Barke, Edmund +3 more
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