Results 41 to 50 of about 196,068 (330)

Adolescent D-amphetamine treatment in a rodent model of ADHD: pro-cognitive effects during adolescence and cocaine abuse risk during adulthood [PDF]

, 2015
Attention-deficit/hyperactivity disorder (ADHD) is comorbid with cocaine abuse. Whereas initiating ADHD medication in childhood does not alter later cocaine abuse risk, initiating medication during adolescence may increase risk.
Baskin, Britahny M., Dwoskin, Linda P., Jeon, Sae-Mi, Jordan, Chloe J., Kantak, Kathleen M., Taylor, Danielle M.   +5 more
core   +1 more source

Digital twins to accelerate target identification and drug development for immune‐mediated disorders

FEBS Open Bio, EarlyView.
Digital twins integrate patient‐derived molecular and clinical data into personalised computational models that simulate disease mechanisms. They enable rapid identification and validation of therapeutic targets, prediction of drug responses, and prioritisation of candidate interventions.
Anna Niarakis, Philippe Moingeon
wiley   +1 more source

Sex and Feeding Status Differently Affect Natural Reward Seeking Behavior in Olfactory Bulbectomized Rats

Frontiers in Behavioral Neuroscience, 2018
Substance abuse and depression are common psychiatric disorders with a high rate of comorbidity. Both conditions affect differently men and women and preclinical research has showed many sex differences in drug addiction and depression.
Jana Ruda-Kucerova, Mary Tresa Zanda, Petra Amchova, Walter Fratta, Walter Fratta, Liana Fattore, Liana Fattore   +6 more
doaj   +1 more source

CONCURRENT SCHEDULES: REINFORCER MAGNITUDE EFFECTS [PDF]

Journal of the Experimental Analysis of Behavior, 2003
Five pigeons were trained on pairs of concurrent variable‐interval schedules in a switching‐key procedure. The arranged overall rate of reinforcement was constant in all conditions, and the reinforcer‐magnitude ratios obtained from the two alternatives were varied over five levels.
Jason, Landon, Michael, Davison, Douglas, Elliffe   +2 more
openaire   +2 more sources

Different Behavioral Experiences Produce Distinctive Parallel Changes in, and Correlate With, Frontal Cortex and Hippocampal Global Post-translational Histone Levels. [PDF]

, 2018
While it is clear that behavioral experience modulates epigenetic profiles, it is less evident how the nature of that experience influences outcomes and whether epigenetic/genetic biomarkers could be extracted to classify different types of behavioral ...
Cory-Slechta, Deborah A., Schneider, Jay S., Singh, Garima, Sobolewski, Marissa   +3 more
core   +2 more sources

Re‐Awakening Public Attention to the Silent Pandemic of Cancer Among Older Adults in Low‐ and Middle‐Income Countries

Aging and Cancer, EarlyView.
ABSTRACT As global populations age, cancer is increasingly becoming a leading cause of morbidity and mortality among older adults, particularly in low‐ and middle‐income countries (LMICs). Despite accounting for the majority of new cancer cases and deaths, older individuals remain underrepresented in cancer research, clinical guidelines, and health ...
Ibrahim Bidemi Abdullateef, Sunkanmi Folorunsho, Abdulazeez Opeyemi Abdulganiyu   +2 more
wiley   +1 more source

Nociceptin attenuates the escalation of oxycodone self-administration by normalizing CeA-GABA transmission in highly addicted rats. [PDF]

, 2020
Approximately 25% of patients who are prescribed opioids for chronic pain misuse them, and 5 to 10% develop an opioid use disorder. Although the neurobiological target of opioids is well known, the molecular mechanisms that are responsible for the ...
Carrette, Lieselot LG, de Guglielmo, Giordano, George, Olivier, Kallupi, Marsida, Kononoff, Jenni, Palmer, Abraham A, Schweitzer, Paul, Solberg Woods, Leah C   +7 more
core  

Role of the mesoamygdaloid dopamine projection in emotional learning [PDF]

, 2010
Amygdala dopamine is crucially involved in the acquisition of Pavlovian associations, as measured via conditioned approach to the location of the unconditioned stimulus (US).
AA Grace, AM Murray, AR Wagner, AR Wagner, AR Wagner, BJ Everitt, BJ Everitt, CJ Harmer, CJ Harmer, CW Mueller, DA Powell, E Asan, Emily Salussolia, ES Parker, Gavin D. Phillips, GD Phillips, GD Phillips, GD Phillips, GD Phillips, GD Phillips, GD Phillips, GD Phillips, GE Müller, GJ Mogenson, JA Parkinson, JA Parkinson, JA Rosenkranz, JA Rosenkranz, JL McGaugh, JR Taylor, JV Hinrichs, KA Burke, LJ Freedman, M Fleshler, M McDannald, M Mintz, M Zoli, MT Bardo, NM White, P Blundell, P Blundell, P Holland, P Sokoloff, Paul K. Hitchcott, PJ Lang, PK Hitchcott, PK Hitchcott, PK Hitchcott, PK Hitchcott, PK Hitchcott, Q Greba, RA Wise, RC Lennartz, RJ Scibilia, RM Colwill, SB Ostlund, SR Jones, TE Robinson, TE Robinson, TW Robbins, W Schultz   +60 more
core   +1 more source

A Qualitative Analysis of Patient Perspectives and Preferences in Lupus Management to Guide Lupus Guidelines Development

Arthritis Care &Research, EarlyView.
Objective A patient‐centered approach for chronic disease management, including systemic lupus erythematosus (SLE), aligns treatment with patients’ values and preferences, leading to improved outcomes. This paper summarizes how patient experiences, perspectives, and priorities informed the American College of Rheumatology (ACR) 2024 Lupus Nephritis (LN)
Shivani Garg, Izzy Hartel, Lisa R. Sammaritano, Anca Askanase, Bonnie L. Bermas, Maria Dall'Era, Alí Duarte‐García, Victoria P. Werth, Brad Rovin, Reem A. Mustafa, Amy S. Turner, Bené Williams, Brian L. Ung, Hiya Bhavsar, Monique C. Gore‐Massy, Nahirannette Pulido, Natacha Guerrero, Natalie M. Smith, Wambui Machua, Linda T. Hiraki, Mary Beth Son   +20 more
wiley   +1 more source

Concurrent Schedule Performance with Young Infants [PDF]

, 1980
35 leaves. Advisor: Larry A. Alferink.The problem: In operant research on infant conditioning, extinction sessions often are conducted in demonstrating schedule control over the response.
Bonem, Elliott J.
core   +1 more source