Results 51 to 60 of about 48,899 (225)

Targeting the EpCAM‐AXL axis to overcome drug resistance in lung cancer

Molecular Oncology, EarlyView.
Lung cancer cells often evade therapy by hijacking signaling pathways. We reveal that cleaved EpCAM (sEpCAM) stabilizes the oncogenic protein AXL, driving NF‐κB and STAT3‐mediated chemoresistance. This EpCAM‐AXL axis identifies a high‐risk patient subset with poor prognosis.
Alexa Guerrero‐Alba, Mark Shacker, Timothy P. Fleming, Michael A. Smith, Ross M. Bremner, Narendra V. Sankpal   +5 more
wiley   +1 more source

The C‐terminal truncated splicing variant of NK1R negatively modulates substance P‐stimulated NK1R signaling

FEBS Open Bio, EarlyView.
The neurokinin 1 receptor exists as full‐length (NK1L) and C‐terminally truncated (NK1S) splice variants. We show that NK1S heterodimerizes with NK1L, impairing Gαq coupling and Ca2+ mobilization while enhancing β‐arrestin1 recruitment. NK1S suppresses substance P‐driven gene expression and cell migration, revealing NK1S as an endogenous biased ...
Lan Phuong Nguyen, Duc Trung Nguyen, Minyoung Cho, Jihun Kim, Soyeon In, Thai Uy Nguyen, Sunghoon Hurh, Beom Jin Park, Jong‐Ik Hwang   +8 more
wiley   +1 more source

Long live the cat: Ocelot population viability in a planned reintroduced population in Texas, USA

Ecosphere
Reintroductions are often needed to recover carnivore populations and restore ecological processes. Felids are common subjects of reintroduction efforts, but published population models informing felid reintroduction plans are uncommon, and poor planning
Lindsay A. Martinez, Jason V. Lombardi, Israel D. Parker, Forrest East, Tyler A. Campbell, Roel R. Lopez   +5 more
doaj   +1 more source

Real‐World Safety and Effectiveness of JAK Inhibitors in Systemic Sclerosis: A Propensity‐Matched Study From the EUSTAR Cohort

Arthritis Care &Research, EarlyView.
Objective JAK inhibitors (JAKi) have shown promising effects in early‐phase studies of systemic sclerosis (SSc). We aimed to assess the safety and explore the effectiveness of JAKi compared to conventional immunosuppressants in SSc. Methods A longitudinal retrospective study of the European Scleroderma Trials and Research Group (EUSTAR) cohort was ...
Stefano Di Donato, Marie‐Elise Truchetet, Marco Minerba, Oliver Distler, Juan José Alegre Sancho, Yolanda Braun‐Moscovici, Christina Bergmann, Petros Sfikakis, Jeska K. de Vries‐Bouwstra, Murray Baron, Silvia Bellando‐Randone, Lorenzo Dagna, Christopher P. Denton, Madelon C. Vonk, Vanessa Smith, Ivan Castellvi, Gabriela Riemekasten, Andra Balanescu, Masataka Kuwana, Maria De Santis, Kamal Solanki, Anastas Batalov, Vahan Mukuchyan, Marco Matucci‐Cerinic, Yannick Allanore, Francesco Del Galdo, Michael Hughes, EUSTAR Collaborators   +27 more
wiley   +1 more source

Recovery of tigers in India: Critical introspection and potential lessons

People and Nature, 2021
In a world where biodiversity is on the decline, examples of conservation success especially of large carnivores are of interest to policy makers and conservation practitioners. Herein, we elucidate the conservation actions that have been responsible for
Yadvendradev Jhala, Rajesh Gopal, Vaibhav Mathur, Prodipto Ghosh, Himmat Singh Negi, Sunita Narain, Satya Prakash Yadav, Amit Malik, Rajendra Garawad, Qamar Qureshi   +9 more
doaj   +1 more source

Cost-benefit analysis for the reintroduction of lynx to the UK: main report [PDF]

, 2015
The EU Habitats Directive requires Member States to assess the potential and desirability of reintroducing species which have been lost, and to look at other Member States’ experiences to support such assessments. In light of these requirements, the Lynx
White, Chris, O’Donoghue, Paul, van Maanen, Erwin, Piper, Steve, Smith, Darrell, Eagle, Adam, Smith, Darrell J., Convery, Ian, O'Donoghue, Paul, Rowcroft, Petrina   +9 more
core   +1 more source

The Development of Rheumatoid Arthritis–Specific Ambulatory Care–Sensitive Conditions: Results of a Consensus Process

Arthritis Care &Research, EarlyView.
Objective Ambulatory care–sensitive conditions (ACSCs) serve as indicators of access, quality, and performance of the health system. This study aimed to determine rheumatoid arthritis (RA)‐specific ACSCs for use in the evaluation of care system access and quality.
Kara Irwin, Candace H. Feldman, Claire E. H. Barber, Gabriel Fabreau, Jake Jennings, Scott Patten, Cheryl Barnabe, Inflammatory Arthritis‐Specific ACSC Consensus Process Working Group   +7 more
wiley   +1 more source

Clinical outcomes of intermittent panitumumab based-therapy for previously treated older patient with metastatic colorectal cancer: a case report and review of literature

Frontiers in Oncology
BackgroundMetastatic colorectal cancer is one of the most common causes of cancer death worldwide, and its incidence increases with age. Treating an older RAS and BRAF wild-type patient represents a challenge for the medical oncologist, even more so for ...
Gerardo Rosati, Luigi Annunziata, Enrico Scarano, Francesca Dapoto, Domenico Bilancia   +4 more
doaj   +1 more source

Asiatic Lion: Ecology, Economics, and Politics of Conservation

Frontiers in Ecology and Evolution, 2019
Asiatic lions typify most challenges faced by large carnivores: single population, historical bottlenecks, habitat loss, poaching, and conflict with humans.
Yadvendradev V. Jhala, Kausik Banerjee, Stotra Chakrabarti, Parabita Basu, Kartikeya Singh, Chittaranjan Dave, Keshab Gogoi   +6 more
doaj   +1 more source

Materials‐Driven Additive Manufacturing for Electrical Machines: Qualification‐Oriented Design Beyond Geometric Freedom

Advanced Engineering Materials, EarlyView.
This perspective reframes additive manufacturing for electrical machines as a qualification‐limited materials and architecture design problem. It links process–structure–property–performance relationships to magnetic, conducting, dielectric, and thermal property windows, highlighting where AM can enable segmented magnetic circuits, permanent magnet ...
Dénes Fodor, Loránd Szabó
wiley   +1 more source