Results 41 to 50 of about 830 (187)

A Proteochemometric Model for Ligands of the SLC5 Transporter Family

Archiv der Pharmazie, Volume 359, Issue 1, January 2026.
A novel proteochemometric model was developed to predict the activity and selectivity of SLC5 family inhibitors. The model's performance was validated using 10‐fold cross‐validation on publicly available datasets achieving Q2 = 0.79 and MSE < 0.32. Detailed analysis of the results enabled the identification of a new, previously unrecognized selectivity‐
Martin Juhás, Gerhard Ecker
wiley   +1 more source

The indirect influence of quasars on reionization [PDF]

Monthly Notices of the Royal Astronomical Society: Letters, 2018
ABSTRACT The exact role of quasars during the Epoch of Reionization remains uncertain. With consensus leaning towards quasars producing a negligible amount of ionizing photons, we pose an alternate question: Can quasars indirectly contribute to reionization by allowing ionizing photons from stars to escape more easily?
Jacob Seiler, Anne Hutter, Manodeep Sinha, Darren Croton   +3 more
openaire   +3 more sources

Update and ADMET Profile of the Latin American Natural Product Database: LANaPDB

Molecular Informatics, Volume 44, Issue 11-12, November‐December 2025.
LANaPDB was updated with 1,164 nonduplicate new compounds coming from Argentina and Panama. Moreover, 41 ADMET (absorption, distribution, metabolism, excretion, and toxicity)‐related parameters were determined, and the results were compared with the Universal Natural Products Database and the approved small‐molecule drugs.
Alejandro Gómez‐García, Martin J. Lavecchia, Dionisio A. Olmedo, Pablo N. Solís, José L. Medina‐Franco   +4 more
wiley   +1 more source

Breaking through the cosmic fog: JWST/NIRSpec constraints on ionizing photon escape in reionization-era galaxies

Astronomy & Astrophysics
Aims. The escape fraction of Lyman continuum photons (fesc(LyC)) is the last key unknown in our understanding of cosmic reionization. Directly estimating the escape fraction (fesc) of ionizing photons in the epoch of reionization (EoR) is impossible, due
Giovinazzo Emma, Oesch Pascal A., Weibel Andrea, Meyer Romain A., Witten Callum, Bhagwat Aniket, Brammer Gabriel, Chisholm John, de Graaff Anna, Gottumukkala Rashmi, Jecmen Michelle, Katz Harley, Leja Joel, Marques-Chaves Rui, Maseda Michael, Shivaei Irene, Trebitsch Maxime, Verhamme Anne   +17 more
doaj   +1 more source

Cutoff and Emergence of Dart Leaders in an Unbranched Positive Leader Simulation

Geophysical Research Letters, Volume 52, Issue 19, 16 October 2025.
Abstract Channel cutoff is the process by which an active lightning channel cools down, goes dark, and loses its ability to effectively conduct electricity. Current cutoff precedes several lightning phenomena, notably dart leaders and return strokes, but the process by which a hot, highly‐conducting leader channel can undergo current cutoff is poorly ...
J. G. Pantuso, C. L. da Silva, D. P. Jensen, M. Stock, J. Wemhoner, S. Heckman, B. M. Hare, A. F. R. Leal, R. G. Sonnenfeld, O. Scholten, X.‐M. Shao   +10 more
wiley   +1 more source

Euclid: Discovery of 31 new quasars at 6.6 < z < 7.8★

Astronomy & Astrophysics
We report the discovery of 31 new high-z quasars in the redshift range 6.6 
Yang D., Hennawi J. F., Guarneri F., Wolf J., Belladitta S., Schindler J.-T., Hughes A. C. N., Bañados E., Mortlock D. J., Yang J., Wang F., Fan X., Jahnke K., Stern D., Willott C. J., Barth A. J., Rottgering H. J. A., Varadaraj R. G., Decarli R., Eilers A.-C., Ezziati M., Fu Y., Huang J., Jin X., Kang Y., Martinez-Ramirez L. N., Matsuoka Y., Onoue M., Pello R., Remigio R. P., Tee W. L., Venemans B., Vietri G., Wang B., Abbo L. J., Atek H., Bisogni S., Bosman S. E. I., Bowler R. A. A., Conselice C. J., Davies F. B., Gutierrez C. M., Harikane Y., Rubinur K., Lovell C. C., Magliocchetti M., Matthee J., Ricci F., Scialpi M., Scott D., Spinoglio L., Tarsitano F., Toba Y., Walter F., Weaver J. R., Zamorani G., Altieri B., Amara A., Andreon S., Aussel H., Baccigalupi C., Baldi M., Balestra A., Bardelli S., Battaglia P., Biviano A., Branchini E., Brescia M., Camera S., Cañas-Herrera G., Capobianco V., Carbone C., Carretero J., Castellano M., Castignani G., Cavuoti S., Chambers K. C., Cimatti A., Colodro-Conde C., Congedo G., Conversi L., Copin Y., Courbin F., Courtois H. M., Cropper M., Cuillandre J.-C., Degaudenzi H., De Lucia G., Dolding C., Dole H., Douspis M., Dubath F., Dupac X., Dusini S., Escoffier S., Farina M., Farinelli R., Ferriol S., Finelli F., Fourmanoit N., Frailis M., Franceschi E., Fumana M., Galeotta S., George K., Gillis B., Giocoli C., Gómez-Alvarez P., Gracia-Carpio J., Grazian A., Grupp F., Guzzo L., Gwyn S., Haugan S. V. H., Hoekstra H., Holmes W., Hook I. M., Hormuth F., Hornstrup A., Jhabvala M., Kermiche S., Kubik B., Kuijken K., Kümmel M., Kunz M., Kurki-Suonio H., Le Brun A. M. C., Ligori S., Lilje P. B., Lindholm V., Lloro I., Mainetti G., Maino D., Maiorano E., Mansutti O., Marggraf O., Martinelli M., Martinet N., Marulli F., Massey R. J., McCracken H. J., Medinaceli E., Mei S., Mellier Y., Meneghetti M., Merlin E., Meylan G., Mohr J. J., Mora A., Moresco M., Moscardini L., Munari E., Nakajima R., Neissner C., Nichol R. C., Niemi S.-M., Padilla C., Paltani S., Pasian F., Pedersen K., Percival W. J., Pettorino V., Pires S., Polenta G., Poncet M., Popa L. A., Pozzetti L., Racca G. D., Raison F., Rebolo R., Renzi A., Rhodes J., Riccio G., Rix H.-W., Romelli E., Roncarelli M., Rosset C., Rusholme B., Saglia R., Sakr Z., Sapone D., Sauvage M., Schirmer M., Schneider P., Schrabback T., Secroun A., Seidel G., Serrano S., Sihvola E., Simon P., Sirignano C., Sirri G., Stanco L., Steinwagner J., Tallada-Crespí P., Tereno I., Tessore N., Toft S., Toledo-Moreo R., Torradeflot F., Tutusaus I., Valenziano L., Valiviita J., Vassallo T., Wang Y., Weller J., Zerbi F. M., Zucca E., Fabbian G., Huertas-Company M., Martín-Fleitas J., Monaco P., Scottez V., Viel M.   +213 more
doaj   +1 more source

Therapeutic Implications of Biomolecular Corona on Lipid Nanoparticle‐Based Gene Delivery Systems

Small Science, Volume 5, Issue 9, September 2025.
This image illustrates the role of the biomolecular corona in lipid nanoparticles (LNPs), highlighting its impact on the stability, immune response, biodistribution, and targeted delivery. Formed after injection, the corona influences how LNPs circulate, interact with the cells, and modulate the immune response.
Antonietta Greco, Claudia Corbo
wiley   +1 more source

Signatures of Stellar Reionization of the Universe [PDF]

The Astrophysical Journal, 1997
The high ionization level and universal metallicity (1% solar) of the intergalactic gas at redshifts z<5 implies that nonlinear structure had started to form in the universe at earlier times than we currently probe. In Cold Dark Matter (CDM) cosmologies, the first generation of baryonic objects emerges at redshifts z=10-50.
Haiman, Zoltan, Loeb, Abraham
openaire   +4 more sources

Forecasts for Helium Reionization Detection with Fast Radio Bursts in the Era of Square Kilometre Array

The Astrophysical Journal
The observed dispersion measures (DMs) of fast radio bursts (FRBs) are a good indicator of the amount of ionized material along the propagation paths.
Jun-Jie Wei, Chong-Yu Gao
doaj   +1 more source

Signatures of very massive stars in the epoch of reionization

Astronomy & Astrophysics
We present ultra-deep (≃20 − 30 hours) rest-frame UV spectroscopy with NIRSpec of two UV-bright galaxies at z ∼ 8.7, CEERS-1019 and CEERS-1025 (Zneb ≃ 0.1 Z⊙), obtained as part of the JWST Cycle 4 SPURS large program.
Marques-Chaves R., Martins F., Schaerer D., Dessauges-Zavadsky M., Palacios A.   +4 more
doaj   +1 more source