Results 51 to 60 of about 673,364 (305)

Molecular dynamics simulations of positively selected codons in FcγRI reveal novel biochemical binding properties

FEBS Open Bio, EarlyView.
Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young, Omar Arias‐Gaguancela, Fiona Gibson, Morgan Grainger, Jodie Score, Amit Nathubhai, Mauricio Cafiero, Lee Richard Machado   +7 more
wiley   +1 more source

Role of social environment and social clustering in spread of opinions in co-evolving networks [PDF]

, 2013
Taking a pragmatic approach to the processes involved in the phenomena of collective opinion formation, we investigate two specific modifications to the co-evolving network voter model of opinion formation, studied by Holme and Newman [1].
Herman E. S., Holland P. W., Kempe D., Maulana A., Nishant Malik, Peter J. Mucha, Schelling T. C., Toral R., Webster T. J., Weidlich W.   +9 more
core   +3 more sources

Optimizing photoactivation of PA‐mCherry for optical pooled CRISPR screens

FEBS Open Bio, EarlyView.
Photoactivatable PA‐mCherry finds widespread use to optically tag individual cells. However, confocal 405 nm UV laser‐scanning (normal scan) is much less efficient than widefield UV illumination, limiting the use of PA‐mCherry on confocal instruments. We remedy this limitation by reporting that rapid and repeated confocal scanning with a low‐intensity,
Sravasti Mukherjee, Giulia Zanetti, Bram van den Broek, Kees Jalink   +3 more
wiley   +1 more source

Emerging insights into CC and CXC chemokines and their receptors in Mycobacterium tuberculosis infection

FEBS Open Bio, EarlyView.
The dual roles of CC and CXC chemokines in distinguishing active, latent, and subclinical tuberculosis were reviewed, along with an evaluation of their potential as diagnostic biomarkers and therapeutic targets to advance precision medicine in tuberculosis management. The graphical abstract was generated with AI assistance (Gemini 3.0).
Xuying Yin, Dangsheng Xiao, Jiezuan Yang
wiley   +1 more source

Confessions of a Deluded Westerner [PDF]

, 2018
In this paper, I aim to make two general points. First, I claim that the discussions in Repetti (2017) assume different, sometimes conflicting, notions of free will, so the guiding question of the book is not as clear as it could be.
Brent, Michael
core  

Failing boys and moral panics: perspectives on the underachievement debate [PDF]

, 2003
The paper re-examines the underachievement debate from the perspective of the ‘discourse of derision’ that surrounds much writing in this area.
Arnold R., Arnot M., Arnot M., Barker B., Bentley T., Cattell R.B., Clark B., Cohen M., Cohen S., Connell R.W., Department For Education And Employment, Department of Education And Science, Department of Education And Science, Docking J., Emma Smith, Epstein D., Epstein D., Etag, Francis B., Frankel E., Gillborn D., Gillborn D., Gold M.J., Gorard S., Gorard S., Hayes D., Istance D., Jackson D., Lawrence M., Lawton D., Learner S., Mahony P., Measor L., Murphy P., Myhill D., Pirie M., Platten J., Raphael Reed L., Rimm S.R., Shaw M.C., Spendlove D., Thorndike R.L., Wallace W., Weiner G., Whitmore J.R.   +44 more
core   +1 more source

Elevated Connectivity During Language Processing Is Associated With Cognitive Performance in SeLECTS

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Self‐Limited Epilepsy with Centrotemporal Spikes (SeLECTS) is associated with language impairments despite seizures originating in the motor cortex, suggesting aberrant cross‐network interactions. Here we tested whether functional connectivity in SeLECTS during language tasks predicts language performance.
Wendy Qi, Katharine Lee, Kerry C. Nix, Miguel Menchaca, Xiwei Shé, Lorelei Santa Maria, Wei Wu, Zihuai He, Fiona M. Baumer   +8 more
wiley   +1 more source

GAD65 Antibody ELISA With Extended Reportable Range: Validation and Guidance for Neurological Practice

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To (1) validate GAD65‐ELISA detection and quantification for type 1 diabetes mellitus and autoimmune neurological diagnoses, (2) correlate ELISA results (reference range < 5 IU/mL) with established radioimmunoprecipitation assay (RIA; ≤ 0.02 nmol/L), and (3) define ELISA clinical utility and pitfalls.
Andrew McKeon, Dana Olofson, Diana Anissian, Divyanshu Dubey, Eoin P. Flanagan, Max C. Herman, Sarosh R. Irani, Daniel H. Lachance, Maria A. Willrich, Sean Pittock, John R. Mills, Anastasia Zekeridou   +11 more
wiley   +1 more source

Multivariable Adaptive Harmonic Steady-State Control for Rejection of Sinusoidal Disturbances Acting on an Unknown System

, 2017
This paper presents an adaptive harmonic steady-state (AHSS) controller, which addresses the problem of rejecting sinusoids with known frequencies that act on a completely unknown multi-input multi-output linear time-invariant system.
Hoagg, Jesse B., Kamaldar, Mohammadreza
core   +1 more source

Comprehensive Assessment of Arterial, Tissue, and Venous Collaterals for Evaluating the Infarct Growth Rate: The Multimodal Collateral Score

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Collaterals are crucial factors that influence the infarct growth rate (IGR). We aimed to determine whether a comprehensive multimodal collateral score (MCS), incorporating collateral assessment at the arterial, tissue, and venous levels, is associated with functional independence and provides incremental prognostic value over ...
Giorgio Busto, Umberto Pensato, Ilaria Casetta, Giorgio U. Marcello, Angelo Barra, Anna Poggesi, Edoardo Carlesi, Sara Mancini, Andrea Ginestroni, Vittorio Miele, Alessandro Padovani, Andrea Morotti, Enrico Fainardi   +12 more
wiley   +1 more source