Results 31 to 40 of about 216,694 (240)

Onset of secondary progressive multiple sclerosis is not influenced by current relapsing multiple sclerosis therapies

Multiple Sclerosis Journal - Experimental, Translational and Clinical, 2018
Background Disease-modifying therapies are thought to reduce the conversion rate to secondary progressive multiple sclerosis. Objective To explore the rate, chronology, and contributing factors of conversion to the progressive phase in treated relapsing ...
Francisco Coret, Francisco C Pérez-Miralles, Francisco Gascón, Carmen Alcalá, Arantxa Navarré, Ana Bernad, Isabel Boscá, Matilde Escutia, Sara Gil-Perotin, Bonaventura Casanova   +9 more
doaj   +1 more source

Faster progression to multiple sclerosis disability is linked to neuronal pathways associated with neurodegeneration: An ethnicity study.

PLoS ONE, 2023
Although the causes of multiple sclerosis are largely unknown, genetic and environmental components play an important role. Geographic distribution, varying with latitude, reflects both genetic and environmental influences.
Gil Harari, Michael Gurevich, Mark Dolev, Rina Zilkha Falb, Anat Achiron   +4 more
doaj   +1 more source

Additional file 2: of Sub-analysis of geographical variations in the 2-year observational COPTIMIZE trial of patients with relapsingâ remitting multiple sclerosis converting to glatiramer acetate

, 2015
COPITIMIZE: Main Investigator sites. (DOCX 14 kb)
Tjalf Ziemssen, Gilgun-Sherki, Yossi
openaire   +1 more source

Impact of treatment with dimethyl fumarate on sleep quality in patients with relapsing-remitting multiple sclerosis: A multicentre Italian wearable tracker study

Multiple Sclerosis Journal - Experimental, Translational and Clinical, 2023
Background Sleep disorders are common in patients with multiple sclerosis and have a bidirectional interplay with fatigue and depression. Objective To evaluate the effect of treatment with oral dimethyl fumarate on the quality of sleep in relapsing ...
Giancarlo Comi, Letizia Leocani, Luigi Ferini-Strambi, Marta Radaelli, Gloria D Costa, Roberta Lanzillo, Giacomo Lus, Valentina Bianchi, Sebastiano Traccis, Fioravante Capone, Luigi ME Grimaldi, Giuseppe Salemi, Alessandra Cardillo, Valentina Zipoli,   +14 more
doaj   +1 more source

Additional file 3: of Effect of interferon beta-1a subcutaneously three times weekly on clinical and radiological measures and no evidence of disease activity status in patients with relapsingâ remitting multiple sclerosis at year 1

, 2018
Figure S2. Post hoc analysis of MRI endpoints. (PDF 170 kb)
Traboulsee, Anthony, Li, David, Cascione, Mark, Fang, Juanzhi, Dangond, Fernando, Miller, Aaron   +5 more
openaire   +1 more source

Additional file 1: of Effect of interferon beta-1a subcutaneously three times weekly on clinical and radiological measures and no evidence of disease activity status in patients with relapsingâ remitting multiple sclerosis at year 1

, 2018
Table S1. Baseline characteristics of patients in the PRISMS-2 study (adapted from PRISMS Study Group. Lancet. 1998;352:1498â 504). (DOCX 15 kb)
Traboulsee, Anthony, Li, David, Cascione, Mark, Fang, Juanzhi, Dangond, Fernando, Miller, Aaron   +5 more
openaire   +1 more source

Additional file 2: of Effect of interferon beta-1a subcutaneously three times weekly on clinical and radiological measures and no evidence of disease activity status in patients with relapsingâ remitting multiple sclerosis at year 1

, 2018
Figure S1. Incremental quarterly relapse count over 1 year. (PDF 145 kb)
Traboulsee, Anthony, Li, David, Cascione, Mark, Fang, Juanzhi, Dangond, Fernando, Miller, Aaron   +5 more
openaire   +1 more source

Segmented corpus callosum diffusivity correlates with the Expanded Disability Status Scale score in the early stages of relapsing-remitting multiple sclerosis

Clinics, 2013
OBJECTIVE: The aim of this study was to characterize the microscopic damage to the corpus callosum in relapsing-remitting multiple sclerosis (RRMS) with diffusion tensor imaging and to investigate the correlation of this damage with disability.
Carolina de Medeiros Rimkus, Thiago de Faria Junqueira, Dagoberto Callegaro, Maria Concepcion Garcia Otaduy, Claudia da Costa Leite   +4 more
doaj   +1 more source

Expansion of Neutrophils and Classical and Nonclassical Monocytes as a Hallmark in Relapsing-Remitting Multiple Sclerosis

Frontiers in Immunology, 2020
Neutrophils and monocytes encompassing the classical, intermediate, and nonclassical population constitute the majority of circulating myeloid cells in humans and represent the first line of innate immune defense.
David Haschka, P. Tymoszuk, G. Bsteh, V. Petzer, K. Berek, I. Theurl, T. Berger, G. Weiss   +7 more
semanticscholar   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source