Results 271 to 280 of about 48,921 (341)

Model‐Based Strategy for 6‐Mercaptopurine Treatment in Acute Lymphoblastic Leukemia Maintenance Phase: Prediction of 6‐TGN and 6‐MMP Concentrations to Optimize Treatment

open access: yesPediatric Blood &Cancer, Volume 73, Issue 4, April 2026.
ABSTRACT Introduction Acute lymphoblastic leukemia (ALL) is the most common pediatric cancer. The pro‐drug 6‐mercaptopurine (6‐MP), essential during maintenance, is converted into active 6‐thioguanine (6‐TGN) and toxic 6‐methylmercaptopurine (6‐MMP) metabolites, resulting in marked variability in efficacy and toxicity.
Anne Ravix   +5 more
wiley   +1 more source

Tracheobronchial Stenosis in Granulomatosis With Polyangiitis: Immunosuppressant Use and Airway Dilation Frequency

open access: yesACR Open Rheumatology, Volume 8, Issue 4, April 2026.
Objective Tracheobronchial stenosis (TBS) occurs in 13% to 27% of patients with granulomatosis with polyangiitis (GPA) and may cause life‐threatening airway compromise. Despite advances in treatment, TBS remains difficult to manage, with frequent relapses and high procedural burden.
Brendan Denvir   +5 more
wiley   +1 more source

Relapsing Fever Spirochetes Retain Infectivity After Prolonged in vitro Cultivation

open access: green, 2008
Job E. López   +5 more
openalex   +2 more sources

2026 Update on the Management of Diffuse Large B‐Cell Lymphoma

open access: yesAmerican Journal of Hematology, Volume 101, Issue 4, Page 832-863, April 2026.
ABSTRACT Diffuse large B‐cell lymphoma (DLBCL) is the most common type of NHL in the Western Hemisphere. It comprises a heterogenous group of lymphomas, with different biology and clinical prognoses. R‐CHP remains the backbone of therapy, and frontline therapeutic options in fit patients are pola‐R‐CHP and R‐CHOP, whereas elderly or frail/unfit ...
Elise A. Chong   +2 more
wiley   +1 more source

Treatment Outcomes With Novel Targeted and Immunotherapeutic Regimens in CAYA Hodgkin Lymphoma: A Retrospective Study

open access: yesCancer Innovation, Volume 5, Issue 2, April 2026.
Compared to conventional chemotherapy, treatment with BV‐AVD ± R in CAYA Hodgkin lymphoma patients resulted in comparable response rates (ORR: 96.4% vs. 95.4%) but with a marked reduction in Grade 4 hematologic toxicity (25.6% vs. 61.2%). BV‐AVD monotherapy yielded a higher ORR than BV‐AVD + R (100% vs. 93.9%).
Mengqing Xie   +12 more
wiley   +1 more source

Sustained Belinostat‐Induced Metabolic Response and Tolerability in Heavily Pretreated Relapsed/Refractory Angioimmunoblastic T‐Cell Lymphoma: A Case Report

open access: yesClinical Case Reports, Volume 14, Issue 4, April 2026.
ABSTRACT Angioimmunoblastic T‐cell lymphoma (AITL), a rare and aggressive subtype of peripheral T‐cell lymphoma (PTCL), often demonstrates resistance to standard therapies. The optimal therapeutic approach for relapsed/refractory (R/R) AITL remains therefore uncertain and challenging, with an unmet need for effective treatment options.
Vassiliki Labropoulou   +6 more
wiley   +1 more source

Primary Pulmonary Adenoid Cystic Carcinoma Managed With Definitive Radiochemotherapy: A Case Report

open access: yesClinical Case Reports, Volume 14, Issue 4, April 2026.
Section examined from roght mainstem bronchus showing respiratory lining epithelium, subepithelium showing infiltrative tumor arranged in tubules and cribriform pattern. ABSTRACT Primary pulmonary adenoid cystic carcinoma (ACC) is one of the rare and under‐discussed forms of lung cancer.
Samana Oli   +6 more
wiley   +1 more source

Olmesartan‐induced gastritis with no lower gastrointestinal symptoms: A case report

open access: yesDEN Open, Volume 6, Issue 1, April 2026.
Abstract A 74‐year‐old man with decreased appetite, weight, and heartburn was referred to our hospital. His medications included olmesartan. Esophagogastroduodenoscopy (EGD) revealed antral‐dominant erosive gastritis and nodular mucosa. A gastric biopsy revealed inflammatory cell infiltration.
Satoshi Kosaka   +2 more
wiley   +1 more source

AncientBorreliagenomes document the evolutionary history of louse-borne relapsing fever

open access: yes
Swali P   +31 more
europepmc   +1 more source

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