Results 31 to 40 of about 31,625 (241)

Anti‐PD‐1 Nanobody‐Armored MSLN CAR‐T Therapy for Malignant Mesothelioma: Preclinical and Clinical Studies

Advanced Science, EarlyView.
A novel therapy using engineered immune cells (NAC‐T cells) showed promise for refractory malignant mesothelioma. Based on the encouraging preclinical data, the first‐in‐human trial is initiated, demonstrating tolerable safety and promising anti‐tumor activity (ORR 63.6%, DCR 100%, including one CR).
Yan Sun, Haochen Yang, Qing Xu, Xingya Li, Jinxing Lou, Jianchun Duan, Jiachen Xu, Zhuqing Liu, Yong Xia, Zhicai Lin, Linlin Li, Dan Sun, Jiaguo Li, Tao Liu, Jun Guo, Wenfeng Xu, Weimin Zhu, Yi Liu, Boyang Sun, Jia Zhong, Lijie Rong, Qijun Qian, Chenqi Xu, Jie Wang   +23 more
wiley   +1 more source

Real‐World Effectiveness of Switching to Oral or Infusion Versus Injectable Disease‐Modifying Therapy in Pediatric Multiple Sclerosis

Annals of Neurology, EarlyView.
Objective To assess real‐world effectiveness of switching disease‐modifying therapy (DMT) in pediatric multiple sclerosis (MS) and clinically isolated syndrome (CIS) initially treated with platform injectables on disease activity. Methods Of 2615 pediatric‐onset demyelinating disease patients at 12 clinics in the United States (US) Network of Pediatric
Aaron W. Abrams, Michael Waltz, T. Charles Casper, Gregory Aaen, Leslie A. Benson, Eva‐Chava M. Bernfeld, Leigh E. Charvet, Tanuja Chitnis, Carla Francisco, Mark P. Gorman, Jennifer S. Graves, Lauren Krupp, Kimberly O'Neill, Timothy E. Lotze, Soe Mar, Jayne Ness, Mary Rensel, Moses Rodriguez, John Rose, Alice Rutatangwa, Teri Schreiner, Nikita Shukla, Jan‐Mendelt Tillema, Bianca Weinstock‐Guttman, Yolanda Wheeler, Emmanuelle Waubant, Kristen M. Krysko, on behalf of the US Network of Pediatric MS Centers   +27 more
wiley   +1 more source

Case Report and Genetic Sequence Analysis of Candidatus Borrelia kalaharica, Southern Africa

Emerging Infectious Diseases, 2018
Tickborne relapsing fever caused by Borrelia species is rarely reported in travelers returning from Africa. We report a case of a 71-year-old woman who sought treatment at University Medical Center in Freiburg, Germany, in 2015 with recurrent fever after
Katarina Stete, Siegbert Rieg, Gabriele Margos, Georg Häcker, Dirk Wagner, Winfried V. Kern, Volker Fingerle   +6 more
doaj   +1 more source

THE FAUNA OF ARGASIDAE AND THE ROLE OF ORNITHODOROS IN RELAPSING FEVER IN SOME VILLAGES OF THE CENTRAL PROVINCE OF IRAN

Iranian Journal of Public Health, 1996
In order to study the distribution of Argasidae family ticks and the role of O.tholozani in transmitting the relapsing fever agent in rural areas of central province, an investigation was carried out from June to November 1992.
M. Salimi, M. Asmar, N. Piazak   +2 more
doaj  

Borrelia hispanica Relapsing Fever, Morocco

Emerging Infectious Diseases, 2009
We found that 20.5% of patients with an unexplained fever in northwestern Morocco had tick-borne relapsing fever. Molecular detection specific for the 16S rRNA gene identified Borrelia hispanica.
M’hammed Sarih, Martine Garnier, Najma Boudebouch, Ali Bouattour, Abdelaziz Rihani, Mohammed Hassar, Lise Gern, Danièle Postic, Muriel Cornet   +8 more
doaj   +1 more source

Expert Perspective: Diagnosis and Treatment of Castleman Disease

Arthritis &Rheumatology, EarlyView.
Castleman disease (CD) is a major diagnostic challenge for rheumatologists. Unicentric CD (UCD) involves one enlarged lymph node region, whereas multicentric CD (MCD) involves multiple enlarged lymph node regions. Both UCD and MCD may exhibit a wide range of symptoms that overlap with other immune‐mediated conditions.
Luke Y. C. Chen, Lu Zhang, David C. Fajgenbaum   +2 more
wiley   +1 more source

Systematic investigation of the Borrelia miyamotoi spirochetes in ticks, wildlife and domestic animal hosts in Yunnan province, Southwest China

One Health
Background: Borrelia miyamotoi is a spirochete species transmitted via hard ticks. Following its discovery in Japan, this pathogen has been detected around the world, and is increasingly confirmed as a human pathogen causing febrile disease, namely ...
Chun-Hong Du, Ji-Hu Yang, Ming-Guo Yao, Bao-Gui Jiang, Yun Zhang, Zhi-Hai He, Rong Xiang, Zong-Ti Shao, Chun-Feng Luo, En-Nian Pu, Lin Huang, Yu-Qiong Li, Fan Wang, Shuang-Shuang Bie, Zhi Luo, Chao-Bo Du, Jie Zhao, Miao Li, Yi Sun, Jia-Fu Jiang   +19 more
doaj   +1 more source

Multiplex real-time PCR diagnostic of relapsing fevers in Africa. [PDF]

PLoS Neglected Tropical Diseases, 2013
BACKGROUND:In Africa, relapsing fever borreliae are neglected arthropod-borne pathogens causing mild to deadly septicemia and miscarriage. The closely related Borrelia crocidurae, Borrelia duttonii, Borrelia recurrentis and Borrelia hispanica are rarely ...
Haitham Elbir, Mireille Henry, Georges Diatta, Oleg Mediannikov, Cheikh Sokhna, Adama Tall, Cristina Socolovschi, Sally J Cutler, Kassahum D Bilcha, Jemal Ali, Dayana Campelo, Steven C Barker, Didier Raoult, Michel Drancourt   +13 more
doaj   +1 more source

The efficacy of Telitacicept in Childhood‐onset Systemic Lupus Erythematosus: a prospective multi‐center cohort study with IPTW‐adjusted comparison to a historical control group treated with Belimumab

Arthritis &Rheumatology, Accepted Article.
Objective The therapeutic effects of Telitacicept combined with standard of care (SoC) in childhood‐onset systemic lupus erythematosus (cSLE) remain unclear. This study aims to evaluate its efficacy in comparison with Belimumab combined with SoC. Methods We performed a prospective cohort study across 7 tertiary hospitals in China, enrolling patients ...
Chong Luo, Shu Su, Jingyue Liu, Junyu Lin, Jin Song, Zongwen Chen, Yuanyuan Peng, Lijun Jiang, Meng Jia, Li Wang, Xinhui Jiang, Wei Zhang, Zanhua Rong, Bo zhao, Yajun Wang, Xuemei Tang   +15 more
wiley   +1 more source

Tick-borne Relapsing Fever Caused by Borrelia hermsii, Montana

Emerging Infectious Diseases, 2003
Five persons contracted tick-borne relapsing fever after staying in a cabin in western Montana. Borrelia hermsii was isolated from the blood of two patients, and Ornithodoros hermsi ticks were collected from the cabin, the first demonstration of this ...
Tom G. Schwan, Paul F. Policastro, Zachary Miller, Robert L. Thompson, Todd Damrow, James E. Keirans   +5 more
doaj   +1 more source