Results 141 to 150 of about 76,297,564 (315)

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Applying Natural Language Processing Techniques for Sentence-Level Relation Extraction: Analysis and Performance Evaluation

, 2023
openThis study explores the field of sentence-level relation extraction in the context of natural language processing (NLP) applications. We have analyzed many approaches, including document-level relation extraction, in the goal of creating a reliable ...
TUNCER, MERVE
core  

Decoding the dynamic extracellular matrix in cancer—3D models and bioscaffolds rewire the rules of tumor progression

FEBS Letters, EarlyView.
Cancer progression is regulated by the dynamic matrix code of the tumor microenvironment, which influences cellular behavior and disease development. Importantly, matrix remodeling in three‐dimensional cancer models more accurately reflects in vivo conditions compared to conventional two‐dimensional systems.
Sylvia Mangani, Konstantinos Spanopoulos, Zoi Piperigkou, Nikos K. Karamanos   +3 more
wiley   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

Perceived group discrimination and psychological well-being in ethnic minority adolescents

, 2018
Few studies have examined the relation of perceived group discrimination and psychological well-being. Yet, there are theoretical reasons to expect such a relation, and members of ethnic minorities usually perceive higher levels of group discrimination ...
Stevens, Gonneke W.J.M., Leerstoel Verkuijten, Migration, Cultural Diversity and Ethnic Relation, Thijs, Jochem, Leerstoel Finkenauer, Youth in Changing Cultural Contexts   +5 more
core   +1 more source

Patient's Attitude towards the Faculty of Medicine Siriraj Hospital's Information Services

Siriraj Medical Journal, 2004
Objectives : To study an association between patients' demographics and their attitudes including their attitudes towards the Faculty of Medicine Siriraj Hospital' s Information Services.
Panee Charoensethamaha
doaj  

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

FEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang, Hyo Been Jin, Chang Min Kim, So Yeon Lee, Hyun Ho Park   +4 more
wiley   +1 more source

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

Penser la relation avec John Dewey (L'art comme expérience)

, 2016
Pour le travail qui suit et qui participe à un atelier de lecture (voir http://redila.hypotheses.org/category/lire-un-livre-a-plusieurs/john-dewey), les citations font référence à John Dewey, L’art comme expérience (1934, trad.
Serge Martin
core  

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source