Optimizing Clinical Temporal Relation Extraction With Large Language Models: Comparative Analysis. [PDF]
JMIR Med InformHe J +7 more
europepmc +1 more source
FEBS Letters, EarlyView.Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante +10 more
wiley +1 more source
Leveraging Generative Large Language Models for Temporal Relation Extraction From French Clinical Narratives: Prompt-Chaining Approach. [PDF]
J Med Internet ResBannour N +6 more
europepmc +1 more source
Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry
FEBS Letters, EarlyView.EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri +5 more
wiley +1 more source
The limited effects of social media use on misperceptions Social media's limited role in misperceptions. [PDF]
PLoS OneLi Q +7 more
europepmc +1 more source
On the normalization of a priority vector associated with a reciprocal relation. [PDF]
In this paper we show that the widely used normalization constraint SUM(i=1,n) wi = 1 does not apply to the priority vectors associated with reciprocal relations, whenever additive transitivity is involved.
Matteo Brunelli, Michele Fedrizzi
core
Emerging experimental and computational methods for studying redox‐regulated structural transitions
FEBS Letters, EarlyView.Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass +2 more
wiley +1 more source
Translophagy—A potential link between autophagy impairment and translational errors
FEBS Letters, EarlyView.Neurodegenerative diseases are characterised by the accumulation of abnormal proteins and protein aggregates, but their origin often remains unknown. We propose that selective autophagy removes damaged protein‐making machinery, preventing errors during protein synthesis.
Mykola V. Korolchuk +11 more
wiley +1 more source
The DSMZ Digital Diversity Annotation Hub: a pipeline for database expansion via text mining and human curation. [PDF]
J Integr BioinformQuadros E, Reimer LC, Koblitz J.
europepmc +1 more source
Applying Relation Algebra and RelView to Measures in aSocial Network [PDF]
We present an application of relation algebra to measure players' ‘strength' in a social network with influence between players. In particular, we deal with power, success, and influence of a player as measured by the Hoede-Bakker index, its ...
Rudolf Berghammer +2 more
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