Results 151 to 160 of about 5,797,629 (324)

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Multilingual Relation Extraction: A Survey

IEEE Access
Relation extraction plays a fundamental role in applications of various research fields such as knowledge graph construction, event extraction, and question answering over knowledge graphs, as they often rely on extracting relationships between named ...
Manzoor Ali, Rene Speck, Hamada M. Zahera, Muhammad Saleem, Diego Moussallem, Axel-Cyrille Ngonga Ngomo   +5 more
doaj   +1 more source

Unsupervised Open Relation Extraction

, 2021
The paper describes an approach to open relation extraction based on unsupervised machine learning. The state-of-the-art methods for extracting semantic relations are analyzed. The algorithm of automatic open relation extraction using statistical, syntactic and contextual information is proposed.
Tarasenko, Yaroslav, Petrasova, Svitlana
openaire   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

Spatial relation extraction using relational learning

, 2011
Abstract. The automatic extraction of spatial information is a challenging and novel task with many applications. We motivate our denition of this task and formulate it as an information extraction step prior to mapping to spatial semantics. Each sentence gives rise to several spatial relations between words representing landmarks, trajectors and ...
Kordjamshidi, Parisa, Frasconi, Paolo, van Otterlo, Martijn, Moens, Marie-Francine, De Raedt, Luc   +4 more
openaire   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Distantly Supervised Relation Extraction Method Based on Multi-Level Hierarchical Attention

Information
Distantly Supervised Relation Extraction (DSRE) aims to automatically identify semantic relationships within large text corpora by aligning with external knowledge bases.
Zhaoxin Xuan, Hejing Zhao, Xin Li, Ziqi Chen   +3 more
doaj   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Hyperbolic Graph Convolutional Network Relation Extraction Model Combining Dependency Syntax and Contrastive Learning

International Journal of Computational Intelligence Systems
In current relation extraction tasks, when the input sentence structure is complex, the performance of in-context learning methods based on large language model is still lower than that of traditional pre-train fine-tune models.
Jinzhe Li
doaj   +1 more source