Results 181 to 190 of about 1,302,763 (303)

Exploring transformer models: Fine-tuning VS inference on relation extraction from biomedical texts. [PDF]

Comput Struct Biotechnol J
El Janah H, Nachid-Idrissi Y, Sarrouti M, Najah S.   +3 more
europepmc   +1 more source

Chemical-induced disease relation extraction with dependency information and prior knowledge [PDF]

, 2018
Huiwei Zhou, Shixian Ning, Yunlong Yang, Zhuang Liu, Chengkun Lang, Yingyu Lin   +5 more
openalex   +1 more source

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

Molecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto, Nicolò Gualandi, Ylenia Cortolezzis, Raffaella Picco, Monica Colitti, Francesca D'Este, Mariachiara Gani, Wayne W. Hancock, Giovanni Terrosu, Cristina Degrassi, Francesca Agostini, Claudio Brancolini, Luigi E. Xodo, Eros Di Giorgio   +13 more
wiley   +1 more source

Using large language models for temporal relation extraction from pediatric clinical reports. [PDF]

JAMIA Open
Andrew JJ, Potier J, Garcelon N, Burgun A, Vincent M.   +4 more
europepmc   +1 more source

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

Molecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra, Shamsudheen Karuthedath Vellarikkal, Lixia Li, Hong Sun, Khoa Nguyen, Amber Montano, Suchitra Natarajan, Federica Piccioni, Alex Michael Tamburino, Xin Yu, Aleksandra Katarzyna Olow   +10 more
wiley   +1 more source

Knowledge-augmented pre-trained language models for biomedical relation extraction. [PDF]

BMC Bioinformatics
Sänger M, Leser U.
europepmc   +1 more source

Towards generic relation extraction

, 2009
A vast amount of usable electronic data is in the form of unstructured text. The relation extraction task aims to identify useful information in text (e.g., PersonW works for OrganisationX, GeneY encodes ProteinZ) and recode it in a format such as a relational database that can be more effectively used for querying and automated reasoning.
openaire   +1 more source

Effect of chemotherapy on passenger mutations in metastatic colorectal cancer

Molecular Oncology, EarlyView.
Changes in passenger mutation load and predicted immunotherapy response after chemotherapy treatment. Tumor cells rich with passenger mutations have increased sensitivity to chemotherapy. Correlation of passenger mutations with neoantigen load suggests highly mutated clones promote a more effective response to immunotherapy, and therefore, first‐line ...
Marium T. Siddiqui, Matthew A. Cottam, Muhammad Bilal Mirza, Keeli B. Lewis, Kristen K. Ciombor, Mary Kay Washington, Kamran Idrees   +6 more
wiley   +1 more source

Relation Extraction Using Semantic Information

Computational Linguistics, 2023
Jian Xu, Qin Lu, Minglei Li
doaj   +1 more source

miCDER: a context-aware transformer model for joint miRNA-disease entity and multi-level regulatory relation extraction. [PDF]

BMC Genomics
Shi J, Wang L, Liu L, Su J.
europepmc   +1 more source