Molecular Oncology, EarlyView.Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice +16 more
wiley +1 more source
Grouped semantic-feature relation extraction from texts to represent medicinal-plant property knowledge on social media. [PDF]
Front Artif IntellPechsiri C, Piriyakul I, Pechsiri JS.
europepmc +1 more source
A hybrid attention and dilated convolution framework for entity and relation extraction and mining. [PDF]
Sci Rep, 2023 Shan Y, Lu H, Lou W.
europepmc +1 more source
Potential therapeutic targeting of BKCa channels in glioblastoma treatment
Molecular Oncology, EarlyView.This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak +4 more
wiley +1 more source
Revisiting Relation Extraction in the era of Large Language Models. [PDF]
Proc Conf Assoc Comput Linguist Meet, 2023 Wadhwa S, Amir S, Wallace BC.
europepmc +1 more source
Joint Extraction of Entity and Relation with Information Redundancy Elimination
, 2020 Yuanhao Shen, Jungang Han
openalex +1 more source
Effective therapeutic targeting of CTNNB1‐mutant hepatoblastoma with WNTinib
Molecular Oncology, EarlyView.WNTinib, a Wnt/CTNNB1 inhibitor, was tested in hepatoblastoma (HB) experimental models. It delayed tumor growth and improved survival in CTNNB1‐mutant in vivo models. In organoids, WNTinib outperformed cisplatin and showed enhanced efficacy in combination therapy, supporting its potential as a targeted treatment for CTNNB1‐mutated HB.
Ugne Balaseviciute +17 more
wiley +1 more source
Dynamic taxonomy generation for future skills identification using a named entity recognition and relation extraction pipeline. [PDF]
Front Artif IntellGonzalez-Gomez LJ +6 more
europepmc +1 more source
Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells
Molecular Oncology, EarlyView.We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller +17 more
wiley +1 more source
Enhancing biomedical relation extraction through data-centric and preprocessing-robust ensemble learning approach. [PDF]
Database (Oxford)Meesawad W +5 more
europepmc +1 more source