Results 71 to 80 of about 4,596,905 (247)

Mankind at the Crossroads: Civilizational Shift or Self-destruction

Cadmus, 2019
Society has two parallel lines of development—the Course of History and the Spiral of Social Evolution. Development is determined bilaterally by objective and subjective factors.
Dimitar Tchurovsky
doaj  

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

FEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto, Masatomo So, Ayako Furukawa, Kenji Sugase   +3 more
wiley   +1 more source

Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations

FEBS Letters, EarlyView.
The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas, Brigitta Maruzs, Zsófia E. Kálmán, Tomas Klumpler, Gyula Batta, Bálint Péterfia, Zoltán Gáspári   +6 more
wiley   +1 more source

Financial strain among West-Javanese parents: its association with marital satisfaction and quality of life, and the role of dyadic coping

Frontiers in Psychology
In the past decade, the concept of dyadic coping as a buffer against stress in romantic relationships has received much attention in Western countries, but it has rarely been studied in non-Western countries and among parents with school-aged children ...
Langgersari Elsari Novianti, Langgersari Elsari Novianti, Fredrick Dermawan Purba, Johan C. Karremans, Hendriati Agustiani, Hendriati Agustiani   +5 more
doaj   +1 more source

An unexpected alternative viologen electron mediator site in tungsten‐containing formate dehydrogenase

FEBS Letters, EarlyView.
An unexpected alternative interaction site for ethyl viologen was identified in formate dehydrogenase 1 from Methylorubrum extorquens. Combined mutagenesis, kinetic analysis, and docking revealed that aromatic residues near an iron–sulfur cluster enable flavin mononucleotide‐independent electron transfer, offering a framework for engineering improved ...
Eleni G. Poloniataki, Yong Hwan Kim
wiley   +1 more source

Contribution of the alternative model for DSM-5 personality disorders to relationship satisfaction

Frontiers in Psychiatry
IntroductionPersonality is a central factor associated with relationship discord, conflicts, and separation, as well as with dyadic adjustment and relationship stability. The Alternative Model for Personality Disorders (AMPD) of the DSM-5 offers a hybrid
Claudia Savard, Claudia Savard, Claudia Savard, Mélissa Deschênes, Mélissa Deschênes, Élodie Gagné-Pomerleau, Élodie Gagné-Pomerleau, Maude Payant, Kristel Mayrand, Kristel Mayrand, Marie-Chloé Nolin, Marie-Chloé Nolin, Louis-Alexandre Marcoux, Dominick Gamache, Dominick Gamache, Dominick Gamache   +15 more
doaj   +1 more source

Cell geometry and membrane protein crowding constrain Escherichia coli growth rate, overflow metabolism, respiration, and maintenance energy

FEBS Letters, EarlyView.
The physical dimensions and shape of bacterial cells define the surface area available to acquire nutrients and the volume available for synthesizing proteins and DNA. Here, we use computational systems biology to decode the importance of cell geometry as a major determinant of prokaryotic phenotype, including growth rate and metabolic efficiency. This
Ross P. Carlson, Tomáš Gedeon, Mauricio Garcia Benitez, Campbell Putnam, William R. Harcombe, Radhakrishnan Mahadevan, Ashley E. Beck   +6 more
wiley   +1 more source

A Stochastic Relationship [PDF]

Biophysical Journal, 2015
Voltage-gated sodium and potassium ion channels are responsible for action potential (AP) generation and propagation in neurons. However, many other channels—voltage-gated or otherwise—participate in establishing specific patterns of firing activity, regulating AP shape, spiking frequency, and response to synaptic input.
openaire   +2 more sources

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

Review of Approaches to Creating Control Systems for Solid-State Transformers in Hybrid Distribution Networks

Applied Sciences
Large-scale integration of distributed energy resources (DERs) into distribution networks causes topological-operational situations with multidirectional power flows.
Pavel Ilyushin, Vladislav Volnyi, Konstantin Suslov   +2 more
doaj   +1 more source