Results 71 to 80 of about 1,291,418 (265)

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Blood‐based proteomic profiling reveals context‐dependent changes in BCL2‐associated signaling during taxane therapy in breast cancer patients

FEBS Open Bio, EarlyView.
Chemotherapy side effects significantly impact cancer survivors' quality of life. Using protein levels in blood samples from breast cancer patients before and after 12 weeks of taxane treatment, we detected treatment‐dependent changes in calcium signaling and aging pathways associated with cancer recurrence.
Saira Munshani, Eiman Y. Ibrahim, Rozalyn L. Rodwin, Leah M. Ferrucci, Kim Blenman, Maryam Lustberg, Barbara E. Ehrlich   +6 more
wiley   +1 more source

Relationship Between Retinal Vein Occlusion and Axial Length

Kaohsiung Journal of Medical Sciences, 2003
This study examined whether axial length is a local risk factor for central retinal vein occlusion (CRVO) and branch retinal vein occlusion (BRVO). The study group consisted of 40 patients with unilateral CRVO and 77 patients with unilateral BRVO.
San-Chang Tsai, Hsin-Yi Chen
doaj   +1 more source

Identifying transcription factors controlling the basal expression of human MRP4 highlights a substantial role for Sp1

FEBS Open Bio, EarlyView.
The MRP4 transporter exports several drugs and signaling molecules. Here, we identified key promoter elements regulating basal MRP4 expression. Using reporter assays, we defined a conserved region with essential Sp1 and contributory Ets sites, which controlled basal MRP4 expression.
Debora Singer, Angelique Kragl, Katrin Ziems, Juliane Glaubitz, Sophie Grammbauer, Susanne Hildebrandt, Mladen V. Tzvetkov, Gabriele Jedlitschky   +7 more
wiley   +1 more source

Relationship between frequency, length, and treatment outcome of exacerbations to baseline lung function and lung density in alpha-1 antitrypsin-deficient COPD

International Journal of COPD, 2012
Kesavaperumal Vijayasaratha,1 Robert A Stockley21Lung Investigation Unit, 2Research and Development, University Hospital Birmingham NHS Trust, Birmingham, UKBackground: Diary cards are useful for analyzing exacerbations in chronic obstructive pulmonary ...
Vijayasaratha K, Stockley RA
doaj  

Reproductive Biology of Bogue, Boops boops Linneaus, 1758 in the Aegean Sea and Sea of Marmara, Türkiye

Aquatic Sciences and Engineering
Bogue (Boops boops Linnaeus, 1758) is one of the most economic and common species in Türkiye. The bogue individuals were obtained monthly from the commercial catches of gillnet fisheries from May to August 2024 and purse seine fisheries from September ...
Oğuzhan Ayaz, Yusuf Şen, İsmail Burak Daban, Mukadder Arslan İhsanoğlu, Uğur Özekinci   +4 more
doaj   +1 more source

Molecular dynamics simulations of positively selected codons in FcγRI reveal novel biochemical binding properties

FEBS Open Bio, EarlyView.
Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young, Omar Arias‐Gaguancela, Fiona Gibson, Morgan Grainger, Jodie Score, Amit Nathubhai, Mauricio Cafiero, Lee Richard Machado   +7 more
wiley   +1 more source

Morphometric Traits, Length–Weight Dynamics and Condition Indices of Invasive Vermiculated Sailfin Catfish (Pterygoplichthys disjunctivus) in Bangladesh: Management Implications

Aquaculture, Fish and Fisheries
The vermiculated sailfin catfish (Pterygoplichthys disjunctivus), an invasive species, has rapidly proliferated in Bangladesh's freshwater ecosystems, threatening native biodiversity.
Md. Bayazid Bostami, Md. Lutfor Rahman, Md. Al Zahid, Sadman Sakib, Rupesh Das, Pritam Saha, Most. Nilufa Yeasmin, Md. Habibullah‐Al‐Mamun, Md. Hasan Faruque   +8 more
doaj   +1 more source

Sudden anaerobization in Amphibacillus xylanus increases intracellular labile ferrous iron and inhibits cell growth

FEBS Open Bio, EarlyView.
Abruptly changing from aerobic to anaerobic conditions (sudden anaerobization) induced growth inhibition and a significant increase in intracellular labile ferrous iron in the aerotolerant anaerobe Amphibacillus xylanus. We found that free flavins mediate efficient electron transfer from NADH to ferric iron under anaerobic conditions, suggesting that ...
Shinya Kimata, Yoichi Sakai, Keisuke Tanaka, Etsuro Yoshimura, Ken Kitano, Morio Ishikawa, Tadahiro Nakamoto, Tsutomu Takayama, Hirofumi Inoue, Kaho Nomura, Tomonori Suzuki, Masataka Uchino, Akira Abe, Youichi Niimura   +13 more
wiley   +1 more source

Morphometric and meristic characteristics of pabda catfish (Ompok pabda) reared in biofloc and traditional culture system

Aquaculture, Fish and Fisheries
This study analysed morphometric and meristic characteristics of Ompok pabda from two distinct culture systems, namely biofloc and traditional. Fish samples (90 days old) collected from both culture systems were reared in indoor tanks.
Prianka Paul, Md. Sherazul Islam, Abul Farah Md. Hasanuzzaman   +2 more
doaj   +1 more source