Results 61 to 70 of about 1,409,632 (312)

Interaction of HS1BP3 with cortactin modulates TKS5 localisation, cell secretion and cancer malignancy

Molecular Oncology, EarlyView.
Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen, Kristiane Søreng, Chiara Veroni, Laura Trachsel‐Moncho, Nagham Asp, Robin Gaupset, Lars Gustav Lyckander, Helene Knævelsrud, Lars Eftang, Anne Simonsen   +9 more
wiley   +1 more source

ARM'S-LENGTH RELATIONSHIPS WITHOUT MORAL HAZARD [PDF]

Journal of the European Economic Association, 2010
I show that cutting the flow of information between a principal and an agent can increase the power of the incentives of the agent to reveal private information. (JEL: D23, D82, D86, L20)
openaire   +2 more sources

Growth, length-weight relationship and biological information on the clearhead icefish (Protosalanx hyalocranius Abbott, 1901) in Lake Khanka (Xingkai) [PDF]

, 2012
This paper reports the growth pattern and length-weight relationship and summarizes biological data for the clearhead icefish (Protosalanx hyalocranius) in Lake Khanka (Xingkai), on the border between China and Russia.
Froese, R., Froese, Rainer, Xie, S (reprint author), Chinese Acad Sci, Inst Hydrobiol, Wuhan 430072, Peoples R China., Xie, S., Liu, W., Wang, J., Tang, F. J.   +6 more
core   +1 more source

Interpreting the effects of DNA polymerase variants at the structural level

Molecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi, Karolina Krzesińska, Ludovica Beltrame, Pablo Sánchez‐Izquierdo Besora, Matteo Tiberti, Mef Nilbert, Anna Rohlin, Elena Papaleo   +7 more
wiley   +1 more source

Length-weight and length-length relationships, Relative condition factor and Fulton’s condition factor of Five Cyprinid species in Anzali wetland, southwest of the Caspian Sea

Caspian Journal of Environmental Sciences, 2012
This study was conducted to determine length-weight and length-length relationships, relative condition factor (Krel) and Fulton’s condition factor (K) for five species including Scardinius erythrophtalmus, Carassius auratus gibelio, Cyprinus carpio ...
Moradinasab, Gh., Daliri, M., Ghorbani, R., Paighambari, S.Y., Davoodi, R.   +4 more
doaj  

Measuring newborn foot length to identify small babies in need of extra care: a cross sectional hospital based study with community follow-up in Tanzania. [PDF]

, 2010
BACKGROUND\ud \ud Neonatal mortality because of low birth weight or prematurity remains high in many developing country settings. This research aimed to estimate the sensitivity and specificity, and the positive and negative predictive values of newborn ...
Jaribu Jennie, Marchant Tanya, Tanya Marchant, Jennie Jaribu, Marchant, Tanya, Penfold Suzanne, Joanna Armstrong Schellenberg, Tanner Marcel, Marcel Tanner, Suzanne Penfold, Armstrong Schellenberg, Joanna, Schellenberg Joanna, Penfold, Suzanne, Jaribu, Jennie, Tanner, Marcel   +14 more
core   +1 more source

Proteasome inhibitor, ixazomib prevents topoisomerase‐I degradation and reverses irinotecan resistance in colorectal cancer

Molecular Oncology, EarlyView.
Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata, Koji Ando, Hirofumi Hasuda, Koshi Mimori, Elizabeth C. Unan, Siddhartha Pulukuri, Aahana Tiku, Allison Berger, Eiji Oki, Ajit Bharti, Tomoharu Yoshizumi   +10 more
wiley   +1 more source

Rat superficial masseter operates at long lengths during biting

Scientific Reports
The operating length ranges of mammalian jaw muscles have been estimated using twitch contractions or force measurements at the bite point, prompting a consensus that jaw muscles operate at short lengths on their force-length (FL) curve.
Nicolai Konow, Brandon Reder, Daniel Bartlett, Devin Jenness, Trushti Patel, Jeffrey R. Moore, Robert J. Brocklehurst   +6 more
doaj   +1 more source

On sperm length mean–variance relationships

Journal of Evolutionary Biology
Abstract Sperm length is highly variable within ejaculates, between males, among populations, and across species. While theory makes strong predictions about expected mean sperm size, there is less clarity on variation in sperm, although studies have reported sperm-length variation consistent with some theoretical expectations ...
Hosken, DJ, Fitzpatrick, JL, Pizzari, T, Hodgson, DJ   +3 more
openaire   +3 more sources

Clinical performance of the urine‐based TERT promoter AbsoluteQ Digital PCR for non‐invasive detection of bladder cancer

Molecular Oncology, EarlyView.
A urine‐based digital PCR assay targeting two hotspot TERT promoter variants detected bladder cancer with high sensitivity and no false positives in this case–control cohort. The streamlined AbsoluteQ workflow outperformed Sanger sequencing and supports non‐invasive molecular testing for bladder cancer detection.
Anna Nykel, Izabela Kubiak, Lena Rutkowska, Żaneta Kasprzyk, Łukasz Kępczyński, Michał Bednarek, Dariusz Sobieraj, Jacek Wilkosz, Piotr Kania, Adam Jędrzejczyk, Bogdan Kałużewski, Agnieszka Gach, Tadeusz Kałużewski   +12 more
wiley   +1 more source