Results 101 to 110 of about 4,295,535 (295)

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Forest-mensurational characteristics of oak stands in recreational and health-improving forests of Left-Bank Ukraine

Наукові праці Лісівничої академії наук України
Many scientific works of European and North American scientists are concerned with the study of recreational and health-improving forests. In Ukraine, a number of works have also focused on the study of these types of forest, in particular, in Ternopil ...
Serhii Musiienko, Volodymyr Lukyanets, Vira Bondarenko   +2 more
doaj   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Saha Equation Normalized to Total Atomic Number [PDF]

, 2012
The Saha equation describes the relative number density of consecutive ionization levels of a given atomic species under conditions of thermodynamic equilibrium in an ionized gas.
Fowler, John W.
core  

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

Sintering temperature effect on the electrical conductivity of core–shell structured BaCe0.8Gd0.2O3−δ@Ce0.8Gd0.2O2−δ ceramic

Materials Research Express
In this study, the core–shell structured BaCe _0.8 Gd _0.2 O _3− _δ @Ce _0.8 Gd _0.2 O _2− _δ (BCG@GDC) powders were synthesized by co-precipitation method, and the corresponding core–shell BCG@GDC ceramics were prepared through conventional sintering at
Hao Wang, Bin Meng, Xinyu Ping, Qingqing Yang, Wenlong Zhang, Congcong Fang   +5 more
doaj   +1 more source

Experimental Study on the Dynamic Compressive Response of Sand with Respect to Relative Density and Water Content

Medžiagotyra
This paper presents the findings of dynamic compression tests conducted on sand specimens utilizing a Æ 100 mm Split Hopkinson Pressure Bar (SHPB) apparatus. The study aims to investigate the dynamic response characteristics of sand with varying relative
Shuping SUN, Shu SUN, Qingxian YU, Yongchun LI, Xinwen QIAN   +4 more
doaj   +1 more source

current density (relative local)

, 2019
Citation: 'current density (relative local)' in the IUPAC Compendium of Chemical Terminology, 3rd ed.; International Union of Pure and Applied Chemistry; 2006. Online version 3.0.1, 2019. 10.1351/goldbook.C01453 • License: The IUPAC Gold Book is licensed under Creative Commons Attribution-ShareAlike CC BY-SA 4.0 International for individual terms ...
openaire   +1 more source