Results 31 to 40 of about 390,747 (230)
Revista Brasileira de Engenharia Agrícola e AmbientalThis study aimed to determine the impacts that climate change may cause on the development and evapotranspiration of cowpea, in semi-arid climate region of Northeast Brazil.
Edmilson G. Cavalcante Junior +5 more
doaj +1 more source
Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells
Molecular Oncology, EarlyView.Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son +13 more
wiley +1 more source
Frontiers in Forests and Global ChangeForest ecosystems have a major role in sequestering atmospheric CO2 and as such, their resilience is of upmost importance. In the boreal forest, trees grow only during a short period when air temperature is favourable.
Shalini Oogathoo +6 more
doaj +1 more source
Spanish Journal of Agricultural Research, 2015 Soil cation exchange capacity (CEC) depends on the extent and negative charge density of surfaces of soil mineral and organic components. Soil water sorption also depends on the extent of such surfaces, giving thus way to significant relationships ...
José Torrent +2 more
doaj +1 more source
Pallet loading optimization considering storage time and relative humidity
Journal of Industrial Engineering and Management, 2023 Purpose: This paper studies a 3-dimensional pallet loading problem considering interlock stacking pattern, box dimensions, humidity, and storage time, where overlapping and overhanging are not allowed.
Najat Almasarwah +5 more
doaj +1 more source
Molecular Oncology, EarlyView.Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice +16 more
wiley +1 more source
Journal of Agrometeorology, 2010 An experiment laid out in simple RBD combined over dates of sowing (22nd Feb–D1, 7th March–D2 and 22nd March–D3) and varieties (V1–BT-894-3, V2–Rama and V3–BT-893-1) was carried out in three successive years (2004, 2005 and 2006) at BCKV, W. B.
P. K. CHAKRABORTY +2 more
doaj +1 more source
Effective therapeutic targeting of CTNNB1‐mutant hepatoblastoma with WNTinib
Molecular Oncology, EarlyView.WNTinib, a Wnt/CTNNB1 inhibitor, was tested in hepatoblastoma (HB) experimental models. It delayed tumor growth and improved survival in CTNNB1‐mutant in vivo models. In organoids, WNTinib outperformed cisplatin and showed enhanced efficacy in combination therapy, supporting its potential as a targeted treatment for CTNNB1‐mutated HB.
Ugne Balaseviciute +17 more
wiley +1 more source
Controlled atmospheres against insect pests in museums: a review and some considerations
Journal of Entomological and Acarological Research, 2011 Controlled atmospheres using nitrogen represent a safe and effective method for both objects and human health. The use of this technique against pests in museums has received an increasing amount of interest during the last twenty years. This paper looks
Alessia Berzolla +2 more
doaj +1 more source
ATF4‐mediated stress response as a therapeutic vulnerability in chordoma
Molecular Oncology, EarlyView.We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone +11 more
wiley +1 more source