Results 41 to 50 of about 3,273,882 (269)

An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes

FEBS Letters, EarlyView.
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg, Martine Hjeltnes, Josephine Krieger, Joshua E. Elias, Maria Stensland, Kristian Holm, Xiaojun Jiang, Chuki Khangsar, Tuula A. Nyman, Arthur Kaser, Johannes R. Hov, Tom H. Karlsen, Nicole C. Kaneider, Frode L. Jahnsen, Georg Schneditz   +14 more
wiley   +1 more source

Influence of temperature and relative humidity on patterns formed in dried plasma and serum droplets [PDF]

, 2022
In the present methodological study, we investigated the influence of different evaporation conditions upon patterns formed in desiccated plasma and serum droplets; furthermore, we determined the potential of such patterns to distinguish between four ...
Zurbriggen, Leona, Kokornaczyk, Maria Olga, Baumgartner, Stephan, Schaub, Nadine   +3 more
core   +2 more sources

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

Development and water requirements of cowpea under climate change conditions in the Brazilian semi-arid region

Revista Brasileira de Engenharia Agrícola e Ambiental
This study aimed to determine the impacts that climate change may cause on the development and evapotranspiration of cowpea, in semi-arid climate region of Northeast Brazil.
Edmilson G. Cavalcante Junior, José F. de Medeiros, José Espínola Sobrinho, Vladimir B. Figueirêdo, João P. N. da Costa, Wesley de O. Santos   +5 more
doaj   +1 more source

Modular Living Wall System Response to Relative Humidity and Air Temperature in Malaysia

, 2023
The relative humidity is an essential environmental factor that affects thermal comfort. The influence of relative humidity on thermal comfort was studied in various mediums of green infrastructure.
Azmiah Abd-Ghafar, Mega Suria Hashim, Abd-Ghafar, Azmiah, Amalina Mohd-Fauzi, Mohd-Fauzi, Amalina, Hashim, Mega Suria   +5 more
core   +1 more source

Translophagy—A potential link between autophagy impairment and translational errors

FEBS Letters, EarlyView.
Neurodegenerative diseases are characterised by the accumulation of abnormal proteins and protein aggregates, but their origin often remains unknown. We propose that selective autophagy removes damaged protein‐making machinery, preventing errors during protein synthesis.
Mykola V. Korolchuk, Gailing Ma, Robin Antrobus, Diego Manni, Marco Trevisan‐Herraz, Mustafa Khwaja, Max Brown, Gavin D. Richardson, Masaaki Komatsu, Daniel Erskine, Viktor I. Korolchuk, Tetsushi Kataura   +11 more
wiley   +1 more source

Statistical Analysis of the Air-Cooling Process in a Cowshed

Agriculture, 2023
During the operation of the cooling system, a large array of temperature and humidity values was obtained inside and outside the cowshed. On the basis of the obtained data set, mathematical models of temperature, humidity and temperature–humidity indices
Rolandas Bleizgys, Jonas Čėsna, Savelii Kukharets, Oleksandr Medvedskyi   +3 more
doaj   +1 more source

Structures of mycobacterial 3‐methylcrotonyl‐CoA carboxylase reveal carrier‐domain translocation between catalytic sites

FEBS Letters, EarlyView.
Mycobacterial 3‐methylcrotonyl‐CoA carboxylase uses a mobile biotin‐carrying domain to shuttle a carboxyl group between two catalytic sites, enabling carboxylation of 3‐methylcrotonyl‐CoA during leucine breakdown. Cryo‐electron microscopy captures the carrier at both sites and reveals an inward loop movement that may prevent futile rebinding to the ...
Ajit Yadav, Bogdan I. Florea, Sebastian Geibel   +2 more
wiley   +1 more source

Short communication: Predicting cation exchange capacity from hygroscopic moisture in agricultural soils of Western Europe

Spanish Journal of Agricultural Research, 2015
Soil cation exchange capacity (CEC) depends on the extent and negative charge density of surfaces of soil mineral and organic components. Soil water sorption also depends on the extent of such surfaces, giving thus way to significant relationships ...
José Torrent, María C. del Campillo, Vidal Barrón   +2 more
doaj   +1 more source

A context‐dependent modulatory role for eIF6 in acquired resistance to vemurafenib in melanoma

FEBS Letters, EarlyView.
Acquired resistance to vemurafenib upregulates the translation factor eIF6 in melanoma cells. Silencing eIF6 in resistant cells reduces proliferation and partially restores drug sensitivity, whereas its overexpression increases sensitivity across melanoma lines regardless of BRAF status, via modulation of mTOR, S6K, and MAPK signaling.
George Kyriakopoulos, Antonia Petropoulou, Alexandra Anastogianni, Angelina Bania, Vassilis Stamatakis, Argyris Alexiou, Chi‐Ping Day, Glenn Merlino, Katerina Grafanaki, Constantinos Stathopoulos   +9 more
wiley   +1 more source