Results 41 to 50 of about 409,022 (238)
Molecular Oncology, EarlyView.CIN85 is highly expressed in osteosarcoma, particularly in metastatic lesions. Its overexpression increases cell migration and Matrigel invasion, while silencing CIN85 suppresses these behaviors. Transcriptome analysis shows that CIN85 regulates MMP2, COL3A1, and Akt/mTOR signaling. Targeting these pathways reverses CIN85‐induced motility, highlighting
Iryna Horak +10 more
wiley +1 more source
Effects of relative humidity on animal health and welfare
Journal of Integrative Agriculture, 2017 : Farm animals are sources of meat, milk and eggs for the humans, and animal health ensures the quality and security of these agricultural and sideline products.
Yan XIONG +4 more
doaj +1 more source
Identification of Humidity Sensing Mechanism in MgAl2O4 by Impedance Spectroscopy as Function of Relative Humidity [PDF]
Materials Research, 2018 MgAl2O4 is a humidity sensing material, which high melting point requires high sintering temperatures. In this work, manganese oxide was used as a sintering aid to obtain MgAl2O4 samples sintered at 1350°C with a microstructure suitable for humidity ...
Guilherme Baltar Crochemore +3 more
doaj +2 more sources
Molecular Oncology, EarlyView.Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen +9 more
wiley +1 more source
PADDY DRYING IN MIXED ADSORPTION DRYER WITH ZEOLITE: DRYING RATE AND TIME ESTIMATION
Reaktor, 2013 Recently, the main problem of the rice stock and distribution in Indonesia is the quality degradation as indicated in unpleasant odor (smelly), stained, yellowness, and high percentage of broken rice. This is due to the low of paddy quality dried by from
Mochammad Djaeni +6 more
doaj +1 more source
Molecular Oncology, EarlyView.Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata +10 more
wiley +1 more source
Pallet loading optimization considering storage time and relative humidity
Journal of Industrial Engineering and Management, 2023 Purpose: This paper studies a 3-dimensional pallet loading problem considering interlock stacking pattern, box dimensions, humidity, and storage time, where overlapping and overhanging are not allowed.
Najat Almasarwah +5 more
doaj +1 more source
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
Molecular Oncology, EarlyView.Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura +19 more
wiley +1 more source
Molecular Oncology, EarlyView.We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober +16 more
wiley +1 more source