Results 31 to 40 of about 409,022 (238)

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Development and water requirements of cowpea under climate change conditions in the Brazilian semi-arid region

Revista Brasileira de Engenharia Agrícola e Ambiental
This study aimed to determine the impacts that climate change may cause on the development and evapotranspiration of cowpea, in semi-arid climate region of Northeast Brazil.
Edmilson G. Cavalcante Junior, José F. de Medeiros, José Espínola Sobrinho, Vladimir B. Figueirêdo, João P. N. da Costa, Wesley de O. Santos   +5 more
doaj   +1 more source

Short communication: Predicting cation exchange capacity from hygroscopic moisture in agricultural soils of Western Europe

Spanish Journal of Agricultural Research, 2015
Soil cation exchange capacity (CEC) depends on the extent and negative charge density of surfaces of soil mineral and organic components. Soil water sorption also depends on the extent of such surfaces, giving thus way to significant relationships ...
José Torrent, María C. del Campillo, Vidal Barrón   +2 more
doaj   +1 more source

Association between ecological factors and emergency care visits: The influence of relative humidity

European Psychiatry, 2021
Introduction Psychiatric emergency visits have been associated to several climate variables. However, the influence of relative humidity has been not well stablished. Objectives The analyse the influence of relative humidity on emergency care visits.
D. Hernández-Calle, M.F. Bravo-Ortiz
doaj   +1 more source

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

Precipitation and relative humidity favours tree growth while air temperature and relative humidity respectively drive winter stem shrinkage and expansion

Frontiers in Forests and Global Change
Forest ecosystems have a major role in sequestering atmospheric CO2 and as such, their resilience is of upmost importance. In the boreal forest, trees grow only during a short period when air temperature is favourable.
Shalini Oogathoo, Shalini Oogathoo, Louis Duchesne, Daniel Houle, Daniel Kneeshaw, Nicolas Bélanger, Nicolas Bélanger   +6 more
doaj   +1 more source

Diurnal variation in temperature and humidity profile within sesamum canopy and its impact on growth process under different dates of sowing

Journal of Agrometeorology, 2010
An experiment laid out in simple RBD combined over dates of sowing (22nd Feb–D1, 7th March–D2 and 22nd March–D3) and varieties (V1–BT-894-3, V2–Rama and V3–BT-893-1) was carried out in three successive years (2004, 2005 and 2006) at BCKV, W. B.
P. K. CHAKRABORTY, ASIS MUKHERJEE, MRINAL BISWAS   +2 more
doaj   +1 more source

Statistical Analysis of the Air-Cooling Process in a Cowshed

Agriculture, 2023
During the operation of the cooling system, a large array of temperature and humidity values was obtained inside and outside the cowshed. On the basis of the obtained data set, mathematical models of temperature, humidity and temperature–humidity indices
Rolandas Bleizgys, Jonas Čėsna, Savelii Kukharets, Oleksandr Medvedskyi   +3 more
doaj   +1 more source

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

Controlled atmospheres against insect pests in museums: a review and some considerations

Journal of Entomological and Acarological Research, 2011
Controlled atmospheres using nitrogen represent a safe and effective method for both objects and human health. The use of this technique against pests in museums has received an increasing amount of interest during the last twenty years. This paper looks
Alessia Berzolla, Maria Cristina Reguzzi, Elisabetta Chiappini   +2 more
doaj   +1 more source