Results 91 to 100 of about 4,741,714 (283)

Design and analysis strategies for robust microbiome ageing research

open access: yesFEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik   +5 more
wiley   +1 more source

An analysis of the poverty reduction effects on land transfer: Evidence from rural areas in China.

open access: yesPLoS ONE
This paper develops a multidimensional poverty index (MPI) evaluation system using multiple measures. We use the China Family Panel Study (CFPS) data to build balanced panel data from 2012 to 2018. Employing the probit model to analyze the impact of land
Wenguang Yu   +3 more
doaj   +1 more source

Reconstructing enzyme evolution by protein engineering

open access: yesFEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler   +2 more
wiley   +1 more source

Economic Investigation of Poverty and Income Distribution in Pistachio Cultivating Areas of Kerman Province [PDF]

open access: yesJournal of Nuts, 2018
The study of poverty and income in equality are the most important subjects of social/ economic research in agriculture sector. The present study focuses on poverty and income inequality among pistachio growers in Kerman province.
Reza Sedaghat
doaj  

The main factors of poverty in modern Russian society

open access: yesИзвестия высших учебных заведений. Поволжский регион: Общественные науки, 2023
Background. In modern Russian society, the problem of poverty is relevant, which necessitates the study of the main factors affecting the level of population’s poverty.
A.V. Vakhrushev
doaj   +1 more source

Relative Poverty in Russia: Evidence from Different Thresholds

open access: yes, 2020
The official method of measuring poverty in Russia is based on an absolute approach that uses an expertly calculated subsistence level as a poverty line. However, there is an ongoing debate about the possible use of other approaches to measuring poverty.
E. Slobodenyuk, S. Mareeva
semanticscholar   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

open access: yesFEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj   +3 more
wiley   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

open access: yesFEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta   +3 more
wiley   +1 more source

RELATIVE POVERTY IN TURKEY BETWEEN 1994 AND 2006

open access: yesECONOMICS AND MANAGEMENT, 2012
This article examines relative poverty in Turkey in terms of changes and varying dimensions. It is based on annual and monthly disposable income criteria during the period spanning 1994-2006. In the first part of this study, we discussed conceptualization, measurement and differing approaches to poverty.
Tuncay Guloglu   +2 more
openaire   +3 more sources

Structure‐forward targeting of claudins with synthetic binders

open access: yesFEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

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