Results 121 to 130 of about 6,531,643 (307)
Molecular Oncology, EarlyView.Plasma‐based detection of actionable mutations is a promising approach in lung cancer management. Analysis of ctDNA with a multigene NGS panel identified TP53, KRAS, and EGFR as the most frequently altered, with TP53 and KRAS in treatment‐naïve patients and TP53 and EGFR in previously treated patients.
Giovanna Maria Stanfoca Casagrande +11 more
wiley +1 more source
Molecular Oncology, EarlyView.Urinary LGALS3BP is elevated in bladder cancer patients compared to healthy controls as detected by the 1959 antibody–based ELISA. The antibody shows enhanced reactivity to the high‐mannose glycosylated variant secreted by cancer cells treated with kifunensine (KIF).
Asia Pece +18 more
wiley +1 more source
Observation and Simulation of Mutual Approximations between Five Main Uranian Satellites
The Astronomical JournalMutual approximation is an emerging method for obtaining high-precision astrometric measurements of natural satellites and asteroids. We used the 80 cm YaoAn High Precision Telescope to observe mutual approximation events of the main Uranian satellites ...
Jian Chen +6 more
doaj +1 more source
Survivin and Aurora Kinase A control cell fate decisions during mitosis
Molecular Oncology, EarlyView.Aurora A interacts with survivin during mitosis and regulates its centromeric role. Loss of Aurora A activity mislocalises survivin, the CPC and BubR1, leading to disruption of the spindle checkpoint and triggering premature mitotic exit, which we refer to as ‘mitotic slippage’.
Hana Abdelkabir +2 more
wiley +1 more source
Evaluation of the procedure 1A component of the 1980 US/Canada wheat and barley exploratory experiment [PDF]
Several techniques which use clusters generated by a new clustering algorithm, CLASSY, are proposed as alternatives to random sampling to obtain greater precision in crop proportion estimation: (1) Proportional Allocation/relative count estimator (PA/RCE)
Carnes, J. G., Chapman, G. M.
core +1 more source
Molecular Oncology, EarlyView.CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir +12 more
wiley +1 more source
The measurement of Earth rotation on a deformable Earth [PDF]
Until recently, the methods of geodetic positioning on the Earth were limited to a precision of roughly one part in 10 to the 6th power. At this level of precision, the Earth can be regarded as a rigid body since the largest departure of the Earth from ...
Cannon, W. H.
core +1 more source
Molecular Oncology, EarlyView.Clinical trials on PARP inhibitors in urothelial carcinoma (UC) showed limited efficacy and a lack of predictive biomarkers. We propose SLFN5, SLFN11, and OAS1 as UC‐specific response predictors. We suggest Talazoparib as the better PARP inhibitor for UC than Olaparib.
Jutta Schmitz +15 more
wiley +1 more source
Optimal timing to estimate moose Alces alces demographic parameters using remote cameras
Scientific ReportsObtaining estimates of demographic parameters are fundamental for managing species. However, survey timing and duration influences the precision and accuracy of estimates.
Hailey Boone +6 more
doaj +1 more source
A Minimal Solution for Binocular Camera Relative Pose Estimation Based on the Gravity Prior
Remote SensingHigh-precision positioning is the foundation for the functionality of various intelligent agents. In complex environments, such as urban canyons, relative pose estimation using cameras is a crucial step in high-precision positioning. To take advantage of
Dezhong Chen +3 more
doaj +1 more source