Spatio-temporal relative survival of breast and colorectal cancer in Queensland, Australia 2001-2011
, 2016 Despite improvements in cancer survival across many developed countries, it is unclear how survival is changing over time in small areas. This study investigated changes in breast and colorectal cancer survival across 478 areas over 11 years (2001–2011),
Baade, Peter D +5 more
core +1 more source
Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source
Estimating the Net Survival of Patients with Gastric Cancer in Iran in a Relative Survival Framework
Iranian Journal of Medical Sciences, 2018 Background: Iran is an Eastern Mediterranean region country with the highest rate of gastric cancer. The present study aimed to evaluate the 5-year net survival of patients with gastric cancer in Iran using a relative survival framework.
Fatemeh Paknazar +5 more
doaj
Five-year Relative Survival Rate of Pancreas Cancer in the USA, Europe and Japan [PDF]
Japanese Journal of Clinical Oncology, 2014 Tomohiro, Matsuda, Ayako, Matsuda
openaire +2 more sources
Finding novel vulnerabilities of hypomorphic BRCA1 alleles
Molecular Oncology, EarlyView.Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder +10 more
wiley +1 more source
StatBite: Relative Survival and Incidence Rates: Ductal Carcinoma In Situ [PDF]
JNCI Journal of the National Cancer Institute, 2009 openaire +2 more sources
Five-Year Relative Survival Rate of Colon Cancer in the USA, Europe and Japan [PDF]
Japanese Journal of Clinical Oncology, 2014 Ryoko, Machii, Kumiko, Saika
openaire +2 more sources
Survival rate of gastric and esophageal cancers in Ardabil Province, North-West of Iran [PDF]
Background: Upper gastrointestinal cancer is the most common cancer in Ardabil Province, North-West of Iran, accounting for more than 50% of all cancer deaths in this area.
درخشان, محمدحسین +10 more
core
MITF maintains genome stability in nonmelanocyte lineages
Molecular Oncology, EarlyView.MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir +13 more
wiley +1 more source
The 5-Year Relative Survival Rate of Stomach Cancer in the USA, Europe and Japan [PDF]
Japanese Journal of Clinical Oncology, 2013 Tomohiro, Matsuda, Kumiko, Saika
openaire +2 more sources