Results 181 to 190 of about 860,012 (263)

Epigenetic silencing of the liver‐specific lncRNA LUNAR promotes liver cancer progression via NOTCH activation

Molecular Oncology, EarlyView.
LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang, Hyung Seok Kim, Geum Ok Baek, Moon Gyeong Yoon, Su In Lee, Jee‐Yeong Jeong, Ji Eun Han, Soon Sun Kim, Jae Youn Cheong, Jung Woo Eun   +9 more
wiley   +1 more source

Higher-order interactions enhance the latitudinal tree diversity gradient. [PDF]

Nature
Li Y, Xiao J, Jiang Y, Wright SJ, Mayfield MM, Godoy O, Alonso A, Anderson-Teixeira KJ, Baltzer J, Birch JD, Bissiengou P, Bourg NA, Brockelman W, Burslem DFRP, Cao M, Clay K, Davies SJ, Du Q, Ediriweera S, Feistner A, Fernando ES, Gilbert GS, Hao Z, Holík J, Jiang M, Jin G, Johnson DJ, Jones AS, Král K, Larson AJ, Li B, Lian J, Lin L, Liu F, Liu Y, Liu Z, Lutz JA, Ma K, McMahon SM, McShea W, Memiaghe HR, Mi X, Myers JA, Nasardin M, Nathalang A, O'Brien MJ, Obiang NLE, Parker G, Phillips RP, Qiao X, Ren H, Reynolds G, Rodriguez LJV, Šamonil P, Shen G, Shu Z, Shue J, Swanson ME, Thompson J, Uriarte M, Wang X, Wang X, Wang Y, Yao TL, Ye W, Yu M, Zhang M, Zhu Y, Zimmerman J, He F, Chu C.   +70 more
europepmc   +1 more source

Translating whole‐genome doubling into precision medicine in cancer

Molecular Oncology, EarlyView.
Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley   +1 more source

Multi-level assessment of chronic toxicity of the insect growth regulator lufenuron in the non-target aquatic organism Daphnia magna. [PDF]

Environ Geochem Health
Dane H, Aksakal Ö, Şişman T, Gür C, Alat Ö.   +4 more
europepmc   +1 more source

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

Molecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source

SIZ1-mediated SUMOylation of HAT1 enhances plant thermotolerance in Arabidopsis. [PDF]

Plant J
Lao J, Zhao Y, Yang F, Huang B, Feng M, Luo X, Kong X, Zhao T, Wang H, Han Q, Lin H, Zhang D.   +11 more
europepmc   +1 more source

Interferon beta drives therapy resistance in a patient‐derived model of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Interferon type 1 (IFN‐1) production and signaling is associated with the acquisition of therapy resistance, following chronic DNA damage, via Interferon‐related DNA damage resistance signature (IRDS) gene expression. An alternative, DNA damage‐independent role of sustained IFN‐1 mediated resistance was identified and characterized by the emergence of ...
Ashlyn Conant, Tise Suzuki, Kiera McGivney, V. S. S. Abhinav Ayyadevara, Sharon Asariah, Jay Deng, Ethan Nyein, Jacqueline Coats, Gary Yu, Yevgeniya J. Ioffe, Christian Hurtz, Juli J. Unternaehrer   +11 more
wiley   +1 more source

Effects of Three Sweet Potato Varieties on the Development, Survival, and Reproduction of <i>Spodoptera frugiperda</i> Based on an Age-Stage, Two-Sex Life Table Analysis. [PDF]

Insects
Wang Z, Smagghe G, Long G, Zhu H, Qin S, Zhang Z, Li L.   +6 more
europepmc   +1 more source

CEACAM1 participation in breast cancer progression

Molecular Oncology, EarlyView.
In invasive breast cancer (BC), CEACAM1 shifts from an apical to a uniform membranous/cytoplasmic pattern, or is lost, as tumors dedifferentiate, inversely tracking the Ki‐67 proliferative index. In MCF‐7 cells, only CEACAM1‐4L suppresses proliferation, repressing cell cycle and growth factor genes.
Mykola Lyndin, Irina Kube‐Golovin, Anatolii Romaniuk, Gunther Wennemuth   +3 more
wiley   +1 more source

A novel 3R-compliant ex vivo approach to assess ectoparasiticide repellency against Phlebotomus perniciosus in dogs. [PDF]

Parasite
Sibari A, Weis-Servat G, Liénard E, Salem A, Blondel T, Varloud M, Bouhsira E.   +6 more
europepmc   +1 more source