Results 201 to 210 of about 141,581 (359)

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

Comparing the motion of dark matter and standard model particles on cosmological scales. [PDF]

Nat Commun
Grimm N, Bonvin C, Tutusaus I.
europepmc   +1 more source

A SEMICLASSICAL FRAMEWORK FOR ENERGY: BRIDGING QUANTUM MECHANICS AND RELATIVITY THROUGH LOW-ORDER GRAVITATIONAL CORRECTIONS

Machi García, Abdul Sahib
openalex   +1 more source

On Logical Analysis of Relativity Theories [PDF]

, 2010
Hajnal Andréka, Judit X. Madarász, István Németi, Gergely Székely   +3 more
openalex  

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

Black Holes as Laboratories: Tests of General Relativity. [PDF]

Gen Relativ Gravit
Gregory R, Nissanke S.
europepmc   +1 more source

Dialectics of the Metric Perspective - Velocity, Acceleration, and Relativity in the Resonance Model

Lüders, Florian
openalex   +1 more source

Jürgen Renn (ed): The genesis of general relativity. Sources and interpretations [PDF]

, 2008
Donald Salisbury
openalex   +1 more source

Therapeutic strategies for MMAE‐resistant bladder cancer through DPP4 inhibition

Molecular Oncology, EarlyView.
We established monomethyl auristatin E (MMAE)‐resistant bladder cancer (BC) cell lines by exposure to progressively increasing concentrations of MMAE in vitro. RNA sequencing showed DPP4 expression was increased in MMAE‐resistant BC cells. Both si‐DPP4 and the DPP4 inhibitor sitagliptin suppressed the viability of MMAE‐resistant BC cells.
Gang Li, Shuichi Tatarano, Hirofumi Yoshino, Saeki Saito, Mitsuhiko Tominaga, Junya Arima, Ikumi Fukuda, Takashi Sakaguchi, Ryosuke Matsushita, Yasutoshi Yamada, Hideki Enokida   +10 more
wiley   +1 more source

Analysis of treatment-free survival of patients with advanced melanoma receiving nivolumab as monotherapy or in combination with relatlimab in RELATIVITY-047. [PDF]

J Immunother Cancer
Regan MM, Ascierto PA, Lipson EJ, Palaia J, Moshyk A, Selvan A, Lao CD, Atkins MB, McDermott DF, Potluri R, Ranjan S, Bilthare S, Long GV, Stephen Hodi F, Tawbi H, Schadendorf D.   +15 more
europepmc   +1 more source