Results 41 to 50 of about 306,252 (239)

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

open access: yesFEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka   +11 more
wiley   +1 more source

de Sitter invariant special relativity and galaxy rotation curves

open access: yes, 2019
Owing to the existence of an invariant length at the Planck scale, Einstein special relativity breaks down at that scale. A possible solution to this problem is arguably to replace the Poincar\'e invariant Einstein special relativity by a de Sitter ...
Araujo, A., Lopez, D. F., Pereira, J. G.
core   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

open access: yesFEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li   +2 more
wiley   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

open access: yesFEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee   +3 more
wiley   +1 more source

Student understanding of time in special relativity: simultaneity and reference frames [PDF]

open access: yes, 2002
This article reports on an investigation of student understanding of the concept of time in special relativity. A series of research tasks are discussed that illustrate, step-by-step, how student reasoning of fundamental concepts of relativity was probed.
Scherr, Rachel E.   +2 more
core   +1 more source

About Locality and the Relativity Principle Beyond Special Relativity

open access: yes, 2011
Locality of interactions is an essential ingredient of Special Relativity. Recently, a new framework under the name of relative locality \cite{AmelinoCamelia:2011bm} has been proposed as a way to consider Planckian modifications of the relativistic ...
C. Barcelo   +7 more
core   +1 more source

On relatively normal spaces, relatively regular spaces, and on relative property (a)

open access: yesTopology and its Applications, 1999
The following results concerning relative topological properties are proved: (1) A regular (Tychonoff) space \(Y\) is normal in every larger regular (Tychonoff) space if and only if \(Y\) is Lindelöf or normal almost compact. (2) A functionally Hausdorff space \(Y\) is regular in every larger functionally Hausdorff space if and only if \(Y\) is compact.
Matveev, M.V.   +2 more
openaire   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

open access: yesFEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Relativistic kinematics beyond Special Relativity

open access: yes, 2012
In the context of departures from Special Relativity written as a momentum power expansion in the inverse of an ultraviolet energy scale M, we derive the constraints that the relativity principle imposes between coefficients of a deformed composition law,
D. Mattingly   +3 more
core   +1 more source

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