Results 51 to 60 of about 306,252 (239)

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Geodesic Deviation Equation in f(R) Gravity

, 2011
In this paper we study the Geodesic Deviation Equation (GDE) in metric f(R) gravity. We start giving a brief introduction of the GDE in General Relativity in the case of the standard cosmology.
Castaneda, Leonardo, Guarnizo, Alejandro, Tejeiro, Juan M.   +2 more
core   +1 more source

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

Emergent gravity, violated relativity and dark matter

, 2014
The nonlinear affine Goldstone model of the emergent gravity, built on the nonlinearly realized/hidden affine symmetry, is concisely revisited. Beyond General Relativity, the explicit violation of general invariance/relativity, under preserving general ...
Pirogov, Yu. F.
core   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

Relative natural classes and relative injectivity [PDF]

International Journal of Mathematics and Mathematical Sciences, 2005
Let τ be a hereditary torsion theory on the category R‐Mod of left R‐modules over an associative unitary ring R. We introduce the notion of τ‐natural class as a class of modules closed under τ‐dense submodules, direct sums, and τ‐injective hulls. We study connections between certain conditions involving τ‐(quasi‐)injectivity in the context of τ‐natural
openaire   +3 more sources

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

On Special Relativity with Cosmological Constant

, 2004
Based on the principle of relativity and the postulate of invariant speed and length, we propose the theory of special relativity with cosmological constant ${\cal SR}_{c,R}$ if the invariant length whose square is the inverse of the one-third ...
Aldrovandi, Amelino-Camelia, Amelino-Camelia, Amelino-Camelia, Bacry, Bacry, Beltrami, Bennett, Bin Zhou, Chao-Guang Huang, Derome, Fock, Gao, Gibbons, Guo, Guo, Guo, Gürsey, Han-Ying Guo, Inönü, Kowalski-Glikman, Kowalski-Glikman, Kuo, Snyder, Spivak, Tegmark, Weinberg, Zhan Xu   +27 more
core   +1 more source