Results 81 to 90 of about 141,581 (359)
By dawn or dusk—how circadian timing rewrites bacterial infection outcomes
FEBS Letters, EarlyView.The circadian clock shapes immune function, yet its influence on infection outcomes is only beginning to be understood. This review highlights how circadian timing alters host responses to the bacterial pathogens Salmonella enterica, Listeria monocytogenes, and Streptococcus pneumoniae revealing that the effectiveness of immune defense depends not only
Devons Mo +2 more
wiley +1 more source
Zagadnienia Filozoficzne w Nauce, 2018 Black holes entered scientific literature as early as at the end of eighteenth century. They had been known at that time as dark stars, but their concept did not find its way to physics or astronomy, and had been abandoned for more than one hundred years.
Edward Malec
doaj
Pollution characteristic of VOCs of ambient air in winter and spring in Shijiazhuang City
Journal of Hebei University of Science and Technology, 2015 In order to further explore the pollution characteristics of volatile organic compounds in ambient air in winter and spring in Shijiazhuang City, the pollution characteristics of 62 volatile organic compounds (VOCs), monthly and quarterly variation, the ...
Qing CHANG +3 more
doaj +1 more source
Molecular bases of circadian magnesium rhythms across eukaryotes
FEBS Letters, EarlyView.Circadian rhythms in intracellular [Mg2+] exist across eukaryotic kingdoms. Central roles for Mg2+ in metabolism suggest that Mg2+ rhythms could regulate daily cellular energy and metabolism. In this Perspective paper, we propose that ancestral prokaryotic transport proteins could be responsible for mediating Mg2+ rhythms and posit a feedback model ...
Helen K. Feord, Gerben van Ooijen
wiley +1 more source
Crosstalk between the ribosome quality control‐associated E3 ubiquitin ligases LTN1 and RNF10
FEBS Letters, EarlyView.Loss of the E3 ligase LTN1, the ubiquitin‐like modifier UFM1, or the deubiquitinating enzyme UFSP2 disrupts endoplasmic reticulum–ribosome quality control (ER‐RQC), a pathway that removes stalled ribosomes and faulty proteins. This disruption may trigger a compensatory response to ER‐RQC defects, including increased expression of the E3 ligase RNF10 ...
Yuxi Huang +8 more
wiley +1 more source
Peptide‐based ligand antagonists block a Vibrio cholerae adhesin
FEBS Letters, EarlyView.The structure of a peptide‐binding domain of the Vibrio cholerae adhesin FrhA was solved by X‐ray crystallography, revealing how the inhibitory peptide AGYTD binds tightly at its Ca2+‐coordinated pocket. Structure‐guided design incorporating D‐amino acids enhanced binding affinity, providing a foundation for developing anti‐adhesion therapeutics ...
Mingyu Wang +9 more
wiley +1 more source
Experimental realization of a relativistic harmonic oscillator
New Journal of Physics, 2018 We report the experimental study of a harmonic oscillator in the relativistic regime. The oscillator is composed of Bose-condensed lithium atoms in the third band of an optical lattice, which have an energy–momentum relation nearly identical to that of a
Kurt M Fujiwara +7 more
doaj +1 more source
Polemical Reflections about the Possibility of Controversy in Contemporary Philosophy
Vestnik MGIMO-Universiteta, 2012 On the question whether the controversy in the field of philosophy in our time, the author responds negatively, for the following reasons: in the early ages of the real clash of interests could not be, because all the philosophers were inside ...
Milan Uzelaz
doaj +1 more source
FEBS Letters, EarlyView.This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley +1 more source
Real‐time assay of ribonucleotide reductase activity with a fluorescent RNA aptamer
FEBS Letters, EarlyView.Ribonucleotide reductases (RNR) synthesize DNA building blocks de novo, making them crucial in DNA replication and drug targeting. FLARE introduces the first single‐tube real‐time coupled RNR assay, which enables isothermal tracking of RNR activity at nanomolar enzyme levels and allows the reconstruction of allosteric regulatory patterns and rapid ...
Jacopo De Capitani +4 more
wiley +1 more source