Results 81 to 90 of about 13,952 (268)

Relative systoles of relative-essential 2–complexes [PDF]

Algebraic & Geometric Topology, 2011
We prove a systolic inequality for the phi-relative 1-systole of a phi-essential 2-complex, where phi is a homomorphism from the fundamental group of the complex, to a finitely presented group G. Indeed we show that universally for any phi-essential Riemannian 2-complex, and any G, the area of X is bounded below by 1/8 of sys(X,phi)^2.
Katz, Karin Usadi, Katz, Mikhail G, Sabourau, Stéphane, Shnider, Steven, Weinberger, Shmuel   +4 more
openaire   +3 more sources

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Examining the Einstein-Bergson Controversy about Time Considering the Time-Energy Uncertainty Principle [PDF]

Journal of Philosophical Investigations
This paper revisits the famous 1922 debate between Einstein and Bergson on the nature of time, outlining its central philosophical and scientific points of contention and re-evaluating them in light of developments in quantum physics.
Rahimeh Sufiani, Behrouz Ebrahimi
doaj   +1 more source

Relative natural classes and relative injectivity [PDF]

International Journal of Mathematics and Mathematical Sciences, 2005
Let τ be a hereditary torsion theory on the category R‐Mod of left R‐modules over an associative unitary ring R. We introduce the notion of τ‐natural class as a class of modules closed under τ‐dense submodules, direct sums, and τ‐injective hulls. We study connections between certain conditions involving τ‐(quasi‐)injectivity in the context of τ‐natural
openaire   +3 more sources

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

An isoform of 14‐3‐3 protein regulates transbilayer lipid movement at the plasma membrane

FEBS Letters, EarlyView.
Loss of 14‐3‐3ζ in CHO cells confers resistance to exogenous phosphatidylserine (PS) and impairs endocytosis‐independent inward flip‐flop of fluorescent PS at the plasma membrane. RNAi‐mediated knockdown reproduces this defect, while no additive effect is seen in ATP11C‐deficient cells.
Akiko Yamaji‐Hasegawa, Akira Hattori, Masafumi Tsujimoto, Toshihide Kobayashi   +3 more
wiley   +1 more source

Konštruktivizmus, realizmus a obrat k jazyku

Filosofický časopis, 2021
This paper focuses primarily on the realism-constructivism debate. Firstly, I clarify Goodman’s three main arguments for constructivism, and then I deal with the critical response to this doctrine by proponents of Devittian common-sense realism and ...
Mikušiak, Marek
doaj   +1 more source

Residual tail twisting in ascidian larvae is stabilized by asymmetric myofibrils that resist bilateral symmetry restoration

FEBS Letters, EarlyView.
Ascidian Ciona larvae initially show strong clockwise tail twisting, which is largely corrected during development. However, a small residual twist remains. This study shows that organized helical myofibrils in tail muscles mechanically stabilize this residual asymmetry, preventing complete restoration of bilateral symmetry and revealing how embryos ...
Yuki S. Kogure, Misaki K. Nishio, Satoru Okuda, Kohji Hotta   +3 more
wiley   +1 more source

Black holes: do they exist?

Zagadnienia Filozoficzne w Nauce, 2018
Black holes entered scientific literature as early as at the end of eighteenth century. They had been known at that time as dark stars, but their concept did not find its way to physics or astronomy, and had been abandoned for more than one hundred years.
Edward Malec
doaj