Results 61 to 70 of about 6,752 (264)
Modelling stem cell differentiation related processes—A practical overview for biologists
FEBS Letters, EarlyView.Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar +4 more
wiley +1 more source
Design and analysis strategies for robust microbiome ageing research
FEBS Letters, EarlyView.The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik +5 more
wiley +1 more source
FEBS Letters, EarlyView.CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens +8 more
wiley +1 more source
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
Speed of Light or Composition of Velocities
Annales Mathematicae SilesianaeWe analyze in our paper questions of the theory of relativity. We approach this theory from the point of view of velocities and their composition. This is where the functional equations appear.
Sablik Maciej
doaj +1 more source
Unruh effect of nonlocal field theories with a minimal length
Physics Letters B, 2018 The nonlocal field theory commonly requires a minimal length, and so it appears to formulate the nonlocal theory in terms of the doubly special relativity which makes the speed of light and the minimal length invariant simultaneously. We set up a generic
Yongwan Gim, Hwajin Um, Wontae Kim
doaj +1 more source
Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions
FEBS Letters, EarlyView.The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang +4 more
wiley +1 more source
Teaching general relativity theory in high school: why, what and how
Revista de Enseñanza de la Física, 2017 In this work, which is part of a wider research, the problem of teaching the General Theory of Relativity in sec-ondary school is addressed, even though this theory is scarcely addressed even in physics degree courses.
Irene Arriassecq +2 more
doaj
Relative Cohomology of Algebraic Theories [PDF]
Applied Categorical Structures, 2016 7 pages, latex, v.2 accepted in Applied Categorical ...
openaire +2 more sources
FEBS Letters, EarlyView.The mycobacterial CIII‐CIV respiratory supercomplex is an obligate assembly, encompassing several subunits of unknown functions. We have characterized the intracellular subunit AscF, and show that it is unlikely to be a sensor for metals or nucleotides, but is required for growth on nonfermentable energy sources, and likely works as an adapter for ...
Eni Rile +8 more
wiley +1 more source