Results 231 to 240 of about 932,383 (272)
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The Journal of Pharmacology and Experimental Therapeutics, 1991
The vasoconstrictor effect of NG-monomethyl L-arginine (L-NMMA) is believed to be due to the inhibition of the synthesis of endothelium-derived relaxing factor (EDRF) from L-arginine. Here, we tested a series of guanidino compounds other than L-arginine on the rat aorta preparation with and without endothelium present.
G, Thomas, P W, Ramwell
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The vasoconstrictor effect of NG-monomethyl L-arginine (L-NMMA) is believed to be due to the inhibition of the synthesis of endothelium-derived relaxing factor (EDRF) from L-arginine. Here, we tested a series of guanidino compounds other than L-arginine on the rat aorta preparation with and without endothelium present.
G, Thomas, P W, Ramwell
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Life Sciences, 1993
beta-Adrenoceptors are present on vascular smooth muscle and on endothelium. We investigated whether the endothelial beta-adrenoceptors induce relaxation of rat mesenteric resistance arteries by stimulation of endothelium-derived relaxing factor (EDRF) release.
W M, Blankesteijn, T, Thien
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beta-Adrenoceptors are present on vascular smooth muscle and on endothelium. We investigated whether the endothelial beta-adrenoceptors induce relaxation of rat mesenteric resistance arteries by stimulation of endothelium-derived relaxing factor (EDRF) release.
W M, Blankesteijn, T, Thien
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Advanced Energy Materials
Extracting hot‐carriers before they relax back to the band edge will reduce thermal dissipation above the bandgap, which is one of the primary sources of efficiency loss in perovskite solar cells (PSCs).
Can Wang +12 more
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Extracting hot‐carriers before they relax back to the band edge will reduce thermal dissipation above the bandgap, which is one of the primary sources of efficiency loss in perovskite solar cells (PSCs).
Can Wang +12 more
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American Journal of Physiology-Heart and Circulatory Physiology, 1992
Endothelium-dependent relaxations that are resistant to inhibitors of nitric oxide synthase probably are mediated by endothelium-dependent hyperpolarization of the vascular smooth muscle. Experiments were performed to examine the distribution of this type of relaxation along the arterial tree of the rat by measuring changes in isometric force ...
Illiano, S, Nagao, T, Vanhoutte, PM
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Endothelium-dependent relaxations that are resistant to inhibitors of nitric oxide synthase probably are mediated by endothelium-dependent hyperpolarization of the vascular smooth muscle. Experiments were performed to examine the distribution of this type of relaxation along the arterial tree of the rat by measuring changes in isometric force ...
Illiano, S, Nagao, T, Vanhoutte, PM
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Ng-nitro-l-arginine reduces nonadrenergic, noncholinergic relaxations of human gut
Gastroenterology, 1992The aim of this study was to determine whether nonadrenergic, noncholinergic inhibitory neurotransmission in human circular sigmoid colonic and internal anal sphincter muscle involves release of a nitric oxide-like substance. Colonic and sphincter muscle respond to electrical field stimulation by giving nonadrenergic, noncholinergic relaxations.
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The Journal of Pharmacology and Experimental Therapeutics, 1992
NG-Monomethyl L-arginine (L-NMMA) inhibits endothelium-dependent relaxation. It is widely accepted that this effect is due to the inhibition of L-arginine metabolism. Here we show that L-NMMA antagonizes the vasodilator effects of compounds other than L-arginine. In the endothelium intact rat aorta preparation, L-NMMA antagonizes the relaxation induced
G, Thomas, P W, Ramwell
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NG-Monomethyl L-arginine (L-NMMA) inhibits endothelium-dependent relaxation. It is widely accepted that this effect is due to the inhibition of L-arginine metabolism. Here we show that L-NMMA antagonizes the vasodilator effects of compounds other than L-arginine. In the endothelium intact rat aorta preparation, L-NMMA antagonizes the relaxation induced
G, Thomas, P W, Ramwell
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Biochemical and Biophysical Research Communications, 1990
Endothelium-dependent relaxation mediated by the formation of nitric oxide (NO) from L-arginine, is prevented by the arginine analog NG-monomethyl L-arginine (L-NMMA) (Palmer et al., Biochem. Biophys. Res. Comm. 153:1251-1256 (1988)). In the rat mesenteric arterial bed, incubation with L-NMMA did not prevent acetylcholine-induced relaxation, which ...
A B, Ebeigbe +4 more
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Endothelium-dependent relaxation mediated by the formation of nitric oxide (NO) from L-arginine, is prevented by the arginine analog NG-monomethyl L-arginine (L-NMMA) (Palmer et al., Biochem. Biophys. Res. Comm. 153:1251-1256 (1988)). In the rat mesenteric arterial bed, incubation with L-NMMA did not prevent acetylcholine-induced relaxation, which ...
A B, Ebeigbe +4 more
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Biochemical and Biophysical Research Communications, 1992
We investigated the effects of NG-hydroxy-L-arginine (L-HOArg) and hydroxyguanidine (HOG) on the synthesis and vasorelaxant activity of endothelium-derived relaxing factor (NO) released from the rabbit aortic endothelium. Both L-HOArg (10 microM) and HOG (10 microM) equally potentiated the vasorelaxant activity of NO released by Ach (0.1 or 0.3 microM)
A, Zembowicz +4 more
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We investigated the effects of NG-hydroxy-L-arginine (L-HOArg) and hydroxyguanidine (HOG) on the synthesis and vasorelaxant activity of endothelium-derived relaxing factor (NO) released from the rabbit aortic endothelium. Both L-HOArg (10 microM) and HOG (10 microM) equally potentiated the vasorelaxant activity of NO released by Ach (0.1 or 0.3 microM)
A, Zembowicz +4 more
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European Journal of Pharmacology, 1992
This study was performed to examine whether endothelium-derived relaxing factor (EDRF) influences venous tone and reactivity in vivo. The inferior vena cava and abdominal aorta were studied simultaneously under continuous haemodynamic monitoring in anaesthetised rabbits.
S, Schwarzacher +3 more
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This study was performed to examine whether endothelium-derived relaxing factor (EDRF) influences venous tone and reactivity in vivo. The inferior vena cava and abdominal aorta were studied simultaneously under continuous haemodynamic monitoring in anaesthetised rabbits.
S, Schwarzacher +3 more
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Design Strategies for Improving Oral Bioavailability of Tizanidine: Solid Dispersion Approach
International Journal of Drug Delivery TechnologyTizanidine is a poorly soluble drug that helps relax muscles and lower mild blood pressure. Solid dispersion of tinidazole may improve the solubility of the drug.
Manisha . Saini +3 more
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