Results 91 to 100 of about 2,203,901 (263)

FTSJ3‐Mediated 2′‐O‐Methylation of HSPA5 mRNA Stabilizes BOP1 via SUMOylation to Drive DRP1‐Dependent Mitochondrial Fission and Fatty Acid Oxidation in Lung Squamous Cell Carcinoma

open access: yesAdvanced Science, EarlyView.
The RNA methyltransferase FTSJ3 drives lung squamous cell carcinoma progression by catalyzing 2′‐O‐methylation of HSPA5 mRNA, which stabilizes BOP1 through SUMOylation and activates DRP1/SREBP1‐mediated mitochondrial fission and fatty acid oxidation. Targeting this axis with liposomal siRNA potently suppresses tumor growth and metastasis ABSTRACT Lung ...
Qin Hu   +4 more
wiley   +1 more source

International White Book on DER Protection : Review and Testing Procedures [PDF]

open access: yes, 2011
This white book provides an insight into the issues surrounding the impact of increasing levels of DER on the generator and network protection and the resulting necessary improvements in protection testing practices.
Burt, Graeme   +7 more
core   +1 more source

Enhancing Microgrid Protection Through Adaptive Decentralized Relay Coordination: A Solution to Blinding and Sympathetic Tripping

open access: yesIEEE Access
Integrating Distributed Energy Resources into microgrids modifies the network’s system parameters and causes it to exhibit behaviour, particularly during fault conditions.
Sujatha Balasubramanian   +2 more
doaj   +1 more source

Molecular Bases and Genetic Design of Rice Disease Resistance for Optimized Yield and Sustainable Agriculture

open access: yesAdvanced Science, EarlyView.
This study integrates rice immune perception, signal transduction, and resistance output into a multi‐omics framework. By combining high‐throughput sequencing, phenomics, and AI‐assisted design with marker‐assisted selection, gene editing, and rapid domestication, we aim to accelerate the precise breeding of disease‐resistant rice varieties by ...
Xinyue Hou   +4 more
wiley   +1 more source

Decoding the Neural Circuit Underlying Context‐Cue Association in Retrieval of Morphine Reward Memory

open access: yesAdvanced Science, EarlyView.
Contextual cues recruit the glutamatergic vCA1–dmPFC pathway to retrieve morphine reward memory by reshaping cell‐type‐specific prefrontal microcircuit activity. Distinct regulation of PV+ and SST+ interneurons defines this hippocampal–prefrontal mechanism.
Zhifeng Shi   +8 more
wiley   +1 more source

Design Principles of Electrocatalysts for Industrial‐Scale Water Electrolysis

open access: yesAdvanced Energy Materials, EarlyView.
This Review distills electrocatalyst design for industrial‐scale water electrolysis into integrated principles linking active‐site engineering, phase and lattice modulation, interfacial microenvironment regulation and mass‐transport control. By connecting catalyst families with HER/OER mechanisms and practical operating demands, it outlines pathways ...
Hong Tang, Ce Cui, John Wang
wiley   +1 more source

Multiobjective Optimization of Intelligent Substation Relay Protection System Considering Reliability and Economy

open access: yesJournal of Electrical and Computer Engineering
The relay protection system in intelligent substations ensures the safety and stable operation of power grids. While redundancy configurations enhance reliability, excessive redundancy compromises economic efficiency.
Wenjing Wang   +8 more
doaj   +1 more source

Assessing Government Subsidies for Reducing Pesticide Use: A Meta‐Analysis

open access: yesApplied Economic Perspectives and Policy, EarlyView.
ABSTRACT In the efforts being made by governments to reduce pesticide use, subsidies are an important instrument to encourage farmers to adopt more sustainable practices. Yet, their effectiveness remains uncertain due to diverse designs and contexts.
Gaëlle Leduc   +3 more
wiley   +1 more source

Beyond Canonical CO Oxidation: Structural and Evolutionary Insights Into a Non‐Canonical Carbon Monoxide Dehydrogenase

open access: yesAngewandte Chemie, EarlyView.
Clade B carbon monoxide dehydrogenases (CODHs) remain enigmatic, diverging from canonical CODHs in structure and function. Here, we present the first characterization of Ruminococcus flavefaciens CODH (RfCODH), revealing occluded substrate pathways and attenuated CO oxidation activity.
Maximilian Böhm   +6 more
wiley   +2 more sources

Embedded software security testing technology for relay protection devices

open access: yesDianxin kexue, 2018
As the first defensive line of power grid security,the right actions of delay protection devices can minimize the influence to the electric power system security caused by system or equipment failures.Based on the research of relay protection device ...
Wei DING   +3 more
doaj   +2 more sources

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