Results 61 to 70 of about 2,203,901 (263)

Lactate‐Driven Restriction of Mitochondrial Permeability Transition Promotes Resistance to Chemo‐Immunotherapy by Suppressing Tumor PANoptosis

Advanced Science, EarlyView.
Tumor‐derived lactate establishes a metabolic lock that drives chemo‐immunotherapy resistance by suppressing PANoptosis. Mechanistically, KAT8 lactylates the mitochondrial translocator ANT2, which recruits PGAM5 to dephosphorylate CypD. This cascade restricts mitochondrial permeability transition pore opening, preventing pro‐inflammatory mtDNA leakage.
Sen Zhong, Wenlong Chen, Fanglong Liu, Shengyi Zhou, Bolin Yu, Yuying Wang, Xiqian Zhou, Xuehui Wang, Diya Liu, Zhuoyu Zhang, Xinran Wang, Mounia Lalouly, Yiwen Li, Zhefei Du, Tao Yan, Zhihui Xiao, Zhou Zhou, Huanhuan Zhu, Fengyuan Qian, Bowen Zheng, Lin Fang   +20 more
wiley   +1 more source

Operation monitoring platform of relay protection equipment at distribution network side under the background of new power system

Energy Informatics
The new power system puts forward higher requirements for the functionality, real-time performance and reliability of relay protection equipment. Therefore, this paper designs a monitoring platform for the operation of relay protection equipment at ...
Qingsheng Li, Yu Zhang, Zhaofeng Zhang, Zhen Li   +3 more
doaj   +1 more source

Hexagonal Boron Nitride on Liquid and Single‐Crystal Copper: Operando X‐Ray and Atomistic Insights into Growth and Interfacial Structure

Advanced Science, EarlyView.
Liquid metal catalysts are widely assumed to promote high‐quality 2D growth. In this work, operando experiments and machine‐learning‐accelerated simulations show that hBN on Cu breaks this graphene‐derived expectation, where molten Cu promotes multilayer/3D growth, but re‐solidified single‐crystal Cu stabilizes monolayer formation.
Nikoo Ghanadan, Valentina Rein, Hao Gao, Egor Bersenev, Thomas Sarrazin, Manmeet Kaur Sodhi, Bárbara Canto, Irina Snigireva, Nicolas Gauthier, Anastasios C. Manikas, Costas Galiotis, Maciej Jankowski, Gilles Renaud, Athanasios Dimoulas, Karsten Reuter, Oleg Konovalov, Hendrik H. Heenen, Irene M.N. Groot   +17 more
wiley   +1 more source

Research on state evaluation of relay protection device based on grey correlation degree

Diance yu yibiao
In order to utilize the status information data of the relay protection device, improve the efficiency and quality of operation and maintenance, in this paper, the static historical data and real-time monitoring data of the relay protection device are ...
XU Feng, SHENG Haihua, WU Jiayi, ZHENG Ran, WANG Junhui, YIN Huan, YIN Jianjun   +6 more
doaj   +1 more source

NIR‐II Light‐Triggered Electron Flow Initiates Cuproptosis‐Centered Thermoelectric‐Immunotherapy for Breast Cancer

Advanced Science, EarlyView.
A NIR‐II light‐activatable thermoelectric nanoreactor converts surface‐bound Cu2+ into bioactive Cu+ via directed electron flow. This spatiotemporally controlled reduction triggers potent cuproptosis and immunogenic cell death, eradicating primary tumors and, together with aPD‐1 therapy, suppressing metastases while establishing durable immune memory ...
Boyu Yuan, Qin Fan, Shushu Chu, Shining Yang, Yuechao Yang, Chenxi Zhang, Jinqiao Zhang, Xinran Qu, Yiju Wei, Xin Wang, Ziliang Dong   +10 more
wiley   +1 more source

Quantitative analysis of the influence of asymmetric channel delay on relay protection's reliability

Dianxin kexue, 2019
The asymmetric delay of digital channels has negative effects on line current differential protection in a complex mechanism. Hence, it's necessary to use effective methods to improve the reliability of relay protection.
Huisheng GAO, Qing SHEN
doaj   +2 more sources

Current Status of Relay Protection of Mine 35 kV Power Line and Its Improvement Measures

Gong-kuang zidonghua, 2011
Current status of relay protection of 35 kV power line of a mine was introduced and main problems were pointed out, namely difficult setting of protection value and matching of up-down time limit which usually lead to faults of protection failure and ...
ZHANG Zhao-hua
doaj  

Innovative Practice of Protection Private Communication Network in Suzhou Electric Power Grid

Guangtongxin yanjiu, 2023
【Objective】Focusing on the strategic goal of building an internationally leading energy Internet enterprise with Chinese characteristics, in accordance with the promotion of the deep integration and application of advanced information and communication ...
LAN Jian, WU Haiyang, CHEN Xiangdong, ZHOU Shaoqing, HOU Yabo   +4 more
doaj  

Biomimetic Self‐Reconfigurable Soft Gripper for Cross‐Scale, Multi‐Particle, and High‐Load Multifunctional Manipulation

Advanced Science, EarlyView.
A fully soft, self‐reconfigurable gripper inspired by rapeseed flowers is monolithically 3D‐printed and electronics‐free, switching between diagonal and parallel finger arrangements. Establishing a self‐reconfigurable grasping paradigm, the gripper enables diverse manipulation tasks, including rotating bulbs, picking fruits, grasping cross‐scale ...
Qiping Xu, Bin Wang, Jinxin Chen, Zhengqiang Guo, Baisong Yang, Chaoqian Chen, Jiancheng Cai, Chee‐Meng Chew, Shiju E   +8 more
wiley   +1 more source

Functionalized Biomimetic Scaffolds for Human‐Derived Auditory Neural Circuit Construction

Advanced Science, EarlyView.
In Vitro Auditory Circuit Model. ABSTRACT Damage to auditory circuits results in sensorineural hearing loss. However, the scarcity of human inner ear tissue significantly hinders the development of therapies to preserve auditory function, creating a critical need for reliable in vitro models.
Pan Feng, Qian Zhu, Yusong Wang, Hao Rong, Xu Zhang, Fuchun Wang, Tianqi Yu, Wenxuan Wang, Jing Li, Lei Tian, Menghui Liao, Renjie Chai, Yangnan Hu   +12 more
wiley   +1 more source