Results 1 to 10 of about 6,433,232 (140)

On-demand pH-sensitive surface charge-switchable polymeric micelles for targeting Pseudomonas aeruginosa biofilms development

open access: yesJournal of Nanobiotechnology, 2021
Bacterial biofilm is the complicated clinical issues, which usually results in bacterial resistance and reduce the therapeutic efficacy of antibiotics.
Xiangjun Chen   +6 more
doaj   +1 more source

Elaboration on the architecture of pH-sensitive surface charge-adaptive micelles with enhanced penetration and bactericidal activity in biofilms

open access: yesJournal of Nanobiotechnology, 2021
Background Biofilm formation is one of the main reasons for persistent bacterial infections. Recently, pH-sensitive copolymers have fascinated incredible attention to tackle biofilm-related infections.
Rong Guo   +7 more
doaj   +1 more source

Design and Synthesis of Novel α-Methylchalcone Derivatives, Anti-Cervical Cancer Activity, and Reversal of Drug Resistance in HeLa/DDP Cells

open access: yesMolecules, 2023
In this study, a collection of newly developed α-methylchalcone derivatives were synthesized and assessed for their inhibitory potential against human cervical cancer cell lines (HeLa, SiHa, and C33A) as well as normal human cervical epithelial cells (H8)
Zheng Yang   +5 more
doaj   +1 more source

Modular assembly of indole alkaloids enabled by multicomponent reaction

open access: yesNature Communications, 2023
Indole alkaloids are one of the largest alkaloid classes, proving valuable structural moiety in pharmaceuticals. Although methods for the synthesis of indole alkaloids are constantly explored, the direct single-step synthesis of these chemical entities ...
Jiaming Li   +4 more
doaj   +1 more source

A fluorescence sensor for nitroreductase detection in hypoxic cells and zebrafish

open access: yesResults in Chemistry, 2021
Nitroreductase (NTR) is a type of cytoplasmic enzyme that depends on flavin mononucleotide or flavin adenine dinucleotide, and that is widely present in tumor cells where it increases during hypoxia. NTR can effectively reduce aromatic nitro compounds to
Wan Sun   +7 more
doaj   +1 more source

Hydrogel-Based Microneedle as a Drug Delivery System

open access: yesPharmaceutics, 2023
The skin is considered the largest and most accessible organ in the human body, and allows the use of noninvasive and efficient strategies for drug administration, such as the transdermal drug delivery system (TDDS).
David Filho   +4 more
doaj   +1 more source

RELEASE: A High-level Paradigm for Reliable Large-scale Server Software [PDF]

open access: yes, 2012
Erlang is a functional language with a much-emulated model for building reliable distributed systems. This paper outlines the RELEASE project, and describes the progress in the first six months.
A. Leung   +14 more
core   +1 more source

Nano Composite Fe-Co-V /Zeolite as a Nano Carrier for Folic Acid Drug Controlled Release [PDF]

open access: yesTrends in Pharmaceutical Sciences, 2021
large reserves of zeolites has been one of the comparative advantages of the country in this field and provides economic justification for its use in a variety of applications, including medical and pharmaceutical fields such as artificial kidney ...
Shima Zangeneh Yousef Abadi   +2 more
doaj   +1 more source

A Transformer-Based Ensemble Framework for the Prediction of Protein–Protein Interaction Sites

open access: yesResearch, 2023
The identification of protein–protein interaction (PPI) sites is essential in the research of protein function and the discovery of new drugs. So far, a variety of computational tools based on machine learning have been developed to accelerate the ...
Minjie Mou   +8 more
doaj   +1 more source

Paulo Freire: Review of “The Pedagogy of the Oppressed”

open access: yesHarm Reduction Journal, 2022
Book review of “The Pedagogy of the Oppressed” by Paulo Freire.
André Gomes
doaj   +1 more source

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